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Artery Wall Viscoelasticity: Measurement, Assessment, and Clinical Implications
International Journal of Precision Engineering and Manufacturing ( IF 1.9 ) Pub Date : 2021-05-04 , DOI: 10.1007/s12541-021-00533-x
Kyehan Rhee , Yongwoo Cho

Arteries, which carry blood from the heart to the peripheral tissues, are continuously stressed by pressure pulsation. Pathological changes in arterial walls could cause high-risk cardiovascular diseases, such as heart attack and stroke. Once established, vascular diseases progress by the continual remodeling of the arterial wall, which includes changes in the composition and function of the wall tissues. An arterial wall has both elastic and viscous characteristics, and pathological and degenerative changes in the wall tissue affect the viscoelastic behavior of the artery wall. The arterial viscoelasticity may provide useful information regarding the development and progression of arterial diseases. However, only the wall stiffness has been considered as a clinical diagnostic index for atherosclerosis. Only a few studies have assessed the viscoelasticity of an intact artery, and further studies are necessary to employ the wall viscoelasticity as a physical marker for diagnosing vascular diseases. Accordingly, this study focuses on arterial wall viscosity assessment and its possible clinical applications. In vitro and in vivo tissue viscoelasticity measurement techniques are reviewed, and constitutive models used to assess viscoelastic artery wall behaviors are summarized. Because wall viscoelasticity depends on the tissue composition and function, pathological changes in the arterial wall during atherosclerosis and the contribution of vascular cells to viscoelasticity are discussed. Finally, the recent progress in clinical tools for measuring arterial viscoelasticity is reviewed.



中文翻译:

动脉壁粘弹性:测量,评估和临床意义

将血液从心脏输送到周围组织的动脉在压力脉动的作用下不断受到压力。动脉壁的病理变化可能导致高危心血管疾病,例如心脏病发作和中风。一旦建立,血管疾病就会通过动脉壁的不断重塑而发展,其中包括壁组织的组成和功能的变化。动脉壁既具有弹性特征又具有粘性特征,并且壁组织中的病理和退行性变化会影响动脉壁的粘弹性行为。动脉粘弹性可以提供有关动脉疾病发展和进展的有用信息。然而,仅壁硬度被认为是动脉粥样硬化的临床诊断指标。只有很少的研究评估了完整动脉的粘弹性,而将壁粘弹性用作诊断血管疾病的物理标志物还需要进一步的研究。因此,本研究侧重于动脉壁粘度评估及其可能的临床应用。审查了体外和体内组织粘弹性测量技术,并总结了用于评估粘弹性动脉壁行为的本构模型。因为壁粘弹性取决于组织的组成和功能,所以讨论了动脉粥样硬化期间动脉壁的病理变化以及血管细胞对粘弹性的贡献。最后,综述了用于测量动脉粘弹性的临床工具的最新进展。为了将壁粘弹性用作诊断血管疾病的物理标志物,还需要进一步的研究。因此,本研究侧重于动脉壁粘度评估及其可能的临床应用。审查了体外和体内组织粘弹性测量技术,并总结了用于评估粘弹性动脉壁行为的本构模型。因为壁粘弹性取决于组织的组成和功能,所以讨论了动脉粥样硬化期间动脉壁的病理变化以及血管细胞对粘弹性的贡献。最后,综述了用于测量动脉粘弹性的临床工具的最新进展。为了将壁粘弹性用作诊断血管疾病的物理标志物,还需要进一步的研究。因此,本研究侧重于动脉壁粘度评估及其可能的临床应用。审查了体外和体内组织粘弹性测量技术,并总结了用于评估粘弹性动脉壁行为的本构模型。因为壁粘弹性取决于组织的组成和功能,所以讨论了动脉粥样硬化期间动脉壁的病理变化以及血管细胞对粘弹性的贡献。最后,综述了用于测量动脉粘弹性的临床工具的最新进展。这项研究的重点是动脉壁粘度评估及其可能的临床应用。审查了体外和体内组织粘弹性测量技术,并总结了用于评估粘弹性动脉壁行为的本构模型。因为壁粘弹性取决于组织的组成和功能,所以讨论了动脉粥样硬化期间动脉壁的病理变化以及血管细胞对粘弹性的贡献。最后,综述了用于测量动脉粘弹性的临床工具的最新进展。这项研究的重点是动脉壁粘度评估及其可能的临床应用。审查了体外和体内组织粘弹性测量技术,并总结了用于评估粘弹性动脉壁行为的本构模型。因为壁粘弹性取决于组织的组成和功能,所以讨论了动脉粥样硬化期间动脉壁的病理变化以及血管细胞对粘弹性的贡献。最后,综述了用于测量动脉粘弹性的临床工具的最新进展。因为壁粘弹性取决于组织的组成和功能,所以讨论了动脉粥样硬化期间动脉壁的病理变化以及血管细胞对粘弹性的贡献。最后,综述了用于测量动脉粘弹性的临床工具的最新进展。因为壁粘弹性取决于组织的组成和功能,所以讨论了动脉粥样硬化期间动脉壁的病理变化以及血管细胞对粘弹性的贡献。最后,综述了用于测量动脉粘弹性的临床工具的最新进展。

更新日期:2021-05-04
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