Background

Antidepressant medication is one of the most prescribed medications among Canadians. This medication class has been previously associated with adverse effects. To date, far too little attention has been paid to physical activity (PA) and sedentary behaviors (SB) in adults using antidepressant medication. The study aims to compare objectively measured time in PA and SB behaviors in a population-based sample of adults using antidepressant medication compared to a group of adults not using any psychotropic medication, and to investigate whether these behaviors differ according to four antidepressant classes.

Methods

We used representative data from the Canadian Health Measures Survey (2007–2013). Medication use was documented during an in-house visit. PA and SB were measured by accelerometer. We included 7680 participants aged 18–79 years. A set of weighted analyses of covariance with adjustments for sex, age, body-mass index, income, education level, season, smoking and marital status was conducted to compare mean differences in PA and SB variables between adults using antidepressants and controls.

Results

The cross-sectional weighted prevalence of antidepressant use was 9.3%. Adults using antidepressants completed significantly fewer minutes of moderate to vigorous PA and steps daily compared to adults without psychotropic medication. Daily time spent in light PA and SB were not significantly different between both groups. Sensitivity analyses controlling for self-reported mental and physical health showed no significant difference except smaller time spent in moderate to vigorous PA in adults using SSRI antidepressants than control.

Conclusion

Due to the potential negative side effects associated with antidepressant usage, and the present findings demonstrating lower levels of MVPA in those taking SSRIs, care providers should consider assessing levels of MVPA and if relevant promoting physical activity when prescribing this class of antidepressants.

中文翻译：

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成人使用抗抑郁药并客观测量身体活动和久坐行为：全国代表性的加拿大成年人样本的横断面分析

背景

抗抑郁药是加拿大人中处方最多的药物之一。此类药物以前曾与不良反应相关。迄今为止，使用抗抑郁药对成年人的体育活动（PA）和久坐行为（SB）的关注还很少。这项研究旨在比较使用抗抑郁药物的成年人群与未使用任何精神药物的成年人相比，客观测量的PA和SB行为的时间，并研究这些行为是否根据四种抗抑郁药类别有所不同。

方法

我们使用了来自加拿大卫生措施调查（2007-2013）的代表性数据。内部访问期间记录了药物使用情况。PA和SB用加速度计测量。我们纳入了7680名年龄在18-79岁之间的参与者。进行了一组协方差加权分析，并对性别，年龄，身体质量指数，收入，教育水平，季节，吸烟和婚姻状况进行了调整，以比较使用抗抑郁药和对照组的成年人PA和SB变量的平均差异。

结果

抗抑郁药使用的横断面加权盛行率为9.3％。与未使用精神药物的成年人相比，使用抗抑郁药的成年人每天完成中度至剧烈的PA和步数的时间明显减少。两组之间光PA和SB所花费的每日时间没有显着差异。控制自我报告的身心健康的敏感性分析显示，除使用SSRI抗抑郁药的成年人在中度至剧烈的PA上花费的时间比对照组短外，没有显着差异。

结论

由于与抗抑郁药的使用相关的潜在负面副作用，并且目前的研究结果表明服用SSRI的患者的MVPA较低，因此护理提供者在开此类抗抑郁药时应考虑评估MVPA的水平，以及是否有相关的促进体力活动的作用。