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Rapid Cesium Fluoride Catalyzed Synthesis of 5-Aryloxy-1-phenyl-1Htetrazoles via Nucleophilic Aromatic Substitution
Letters in Organic Chemistry ( IF 0.8 ) Pub Date : 2021-05-01 , DOI: 10.2174/1570178617999200728211046
Syed Muhammad Saad 1 , Shahnaz Perveen 2 , Itrat Fatima 1 , Khalid Mohammed Khan 1
Affiliation  

A nucleophilic aromatic substitution via a new and facile cesium fluoride catalyzed synthetic approach to get 5-aryloxy-1-phenyl-1H-tetrazoles was developed. Dual usage of cesium fluoride as a nucleophilic catalyst as well as an electrophilic catalyst afforded the desired products at room temperature in a short reaction time without purification in high yields. This simple but useful reaction may be a rapid and reliable strategy for the synthesis of tetrazolyl ethers.



中文翻译:

5-芳氧基-1-苯基-1-的快速氟化铯催化合成ħ四唑经由芳香族亲核取代

通过一种新的,简便的氟化铯催化合成方法,开发了亲核芳香族取代基,从而获得了5-芳氧基-1-苯基-1H-四唑。氟化铯作为亲核催化剂和亲电子催化剂的双重使用在室温下以较短的反应时间提供了所需的产物,而没有以高收率进行纯化。这种简单但有用的反应可能是合成四唑基醚的一种快速而可靠的策略。

更新日期:2021-05-04
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