Science Progress ( IF 1.906 ) Pub Date : 2021-05-04 , DOI: 10.1177/00368504211011339 Mohamed A Wahba, Bandar M Alshehri, Mona M Hefny, Rami A Al Dagrer, Safar DS Al-Malki
Acute poisoning is considered one of the most important medical emergencies, resulting in severe morbidity and mortality, and is an economic burden on governments. This study aimed to determine the extent of acute adult intoxication among the population located in the Najran area, Saudi Arabia, over the last 3 years (from January 2017 to December 2019). The study is a hospital-based retrospective observational study. The data of all acutely intoxicated adult patients were collected from patients’ files of King Khalid Hospital, the main hospital in the Najran area. In this study, the total number of intoxicated patients was 852. Patients were divided into three groups according to their age: 15–25 years, 26–35 years and >35 years. Accidental intoxication was predominant (64.6%), especially with therapeutic drugs (60.2%), predominantly acetaminophen and amphetamine, which intoxicated 24.5% and 23.4% of the patients, respectively. Moreover, this study showed that 10.6% of patients were intoxicated with overdoses of alcohol, mostly among patients aged over 35 years. Furthermore, the present study revealed that 23.9% of patients were intoxicated with household chemicals, especially Clorox bleach or Flash. Patients presented with a wide range of symptoms; some were even asymptomatic. Overall, patients’ outcomes were good; mortalities were few (1.2%), and most fatalities were found in patients aged over 35 years (60%). The present study showed that pharmaceutical drugs constituted the most common causative agents in acute intoxication. Household chemicals, especially Clorox bleach, Flash and pesticides, are highly implicated in the acute toxicity problem. Drug abuse, especially amphetamine and alcohol, still represents a great threat facing people from the Najran region. It is crucial to deliver effective public health education programmes to increase community awareness about the predisposing risk factors of acute toxicity, whether as overdoses or suicide attempts.
急性中毒被认为是最重要的医学紧急情况之一，导致严重的发病率和死亡率，是政府的经济负担。这项研究旨在确定过去3年（2017年1月至2019年12月）位于沙特阿拉伯纳吉兰地区的人口中成年人急性中毒的程度。该研究是一项基于医院的回顾性观察性研究。所有急性中毒成年患者的数据均来自Najran地区主要医院King Khalid医院的患者档案。在这项研究中，中毒患者总数为852名。患者根据年龄分为15-25岁，26-35岁和> 35岁三组。意外中毒占大多数（64.6％），尤其是治疗药物（60.2％），主要是对乙酰氨基酚和苯丙胺，分别使24.5％和23.4％的患者中毒。此外，这项研究表明，有10.6％的患者因过量饮酒而中毒，其中大多数是35岁以上的患者。此外，本研究显示23.9％的患者被家用化学药品中毒，尤其是Clorox漂白剂或Flash。患者表现出广泛的症状；有些甚至没有症状。总体而言，患者的预后良好。死亡人数很少（1.2％），大多数死亡发生在35岁以上的患者中（60％）。本研究表明，药物构成急性中毒的最常见病因。家用化学品，特别是Clorox漂白剂，闪蒸剂和杀虫剂，与急性毒性问题高度相关。吸毒，尤其是苯丙胺和酒精，仍然是纳吉兰地区人民面临的巨大威胁。至关重要的是，必须提供有效的公共卫生教育计划，以提高社区对急性毒性的易感危险因素（无论是服药过量还是自杀未遂）的认识。