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Incidence and profile of acute intoxication among adult population in Najran, Saudi Arabia: A retrospective study
Science Progress ( IF 2.1 ) Pub Date : 2021-05-04 , DOI: 10.1177/00368504211011339
Mohamed A Wahba 1, 2 , Bandar M Alshehri 3 , Mona M Hefny 4 , Rami A Al Dagrer 5 , Safar Ds Al-Malki 5
Affiliation  

Acute poisoning is considered one of the most important medical emergencies, resulting in severe morbidity and mortality, and is an economic burden on governments. This study aimed to determine the extent of acute adult intoxication among the population located in the Najran area, Saudi Arabia, over the last 3 years (from January 2017 to December 2019). The study is a hospital-based retrospective observational study. The data of all acutely intoxicated adult patients were collected from patients’ files of King Khalid Hospital, the main hospital in the Najran area. In this study, the total number of intoxicated patients was 852. Patients were divided into three groups according to their age: 15–25 years, 26–35 years and >35 years. Accidental intoxication was predominant (64.6%), especially with therapeutic drugs (60.2%), predominantly acetaminophen and amphetamine, which intoxicated 24.5% and 23.4% of the patients, respectively. Moreover, this study showed that 10.6% of patients were intoxicated with overdoses of alcohol, mostly among patients aged over 35 years. Furthermore, the present study revealed that 23.9% of patients were intoxicated with household chemicals, especially Clorox bleach or Flash. Patients presented with a wide range of symptoms; some were even asymptomatic. Overall, patients’ outcomes were good; mortalities were few (1.2%), and most fatalities were found in patients aged over 35 years (60%). The present study showed that pharmaceutical drugs constituted the most common causative agents in acute intoxication. Household chemicals, especially Clorox bleach, Flash and pesticides, are highly implicated in the acute toxicity problem. Drug abuse, especially amphetamine and alcohol, still represents a great threat facing people from the Najran region. It is crucial to deliver effective public health education programmes to increase community awareness about the predisposing risk factors of acute toxicity, whether as overdoses or suicide attempts.



中文翻译:

沙特阿拉伯奈季兰成年人急性中毒的发病率和概况:一项回顾性研究

急性中毒被认为是最重要的医疗紧急情况之一,会导致严重的发病率和死亡率,并且给政府带来经济负担。本研究旨在确定过去 3 年(2017 年 1 月至 2019 年 12 月)沙特阿拉伯纳吉兰地区人口的急性成人中毒程度。该研究是一项以医院为基础的回顾性观察研究。所有急性中毒成年患者的数据均来自纳季兰地区主要医院哈立德国王医院的患者档案。在这项研究中,中毒患者总数为852人。患者根据年龄分为三组:15-25岁、26-35岁和>35岁。意外中毒占主导地位(64.6%),尤其是治疗药物(60.2%),主要是对乙酰氨基酚和安非他明,分别导致 24.5% 和 23.4% 的患者中毒。此外,这项研究还显示,10.6%的患者因过量饮酒而中毒,其中大多数患者年龄超过35岁。此外,本研究显示,23.9% 的患者因家用化学品中毒,尤其是高乐氏漂白剂或 Flash。患者出现多种症状;有些人甚至没有症状。总体而言,患者的预后良好;死亡率很少(1.2%),大多数死亡病例年龄超过 35 岁(60%)。本研究表明药物是急性中毒最常见的致病因素。家用化学品,特别是高乐氏漂白剂、Flash 和杀虫剂,与急性毒性问题密切相关。药物滥用,特别是安非他明和酒精,仍然是纳吉兰地区人民面临的巨大威胁。提供有效的公共卫生教育计划以提高社区对急性毒性诱发风险因素(无论是用药过量还是自杀未遂)的认识至关重要。

更新日期:2021-05-04
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