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Reactive oxygen species and DNA damage response in cancer
International Review of Cell and Molecular Biology ( IF 6.420 ) Pub Date : 2021-05-03 , DOI: 10.1016/bs.ircmb.2021.04.001
Xavier Renaudin 1
Affiliation  

Compared with normal cells, cancer cells often have an increase in reactive oxygen species (ROS) level. This high level of ROS allows the activation of different pathways essential for cellular transformation and tumorigenesis development. Increase of ROS can be due to increase of production or decrease of detoxification, both situations being well described in various cancers. Oxidative stress is involved at every step of cancer development from the initiation to the metastasis. How ROS arise is still a matter of debates and may vary with tissues, cell types or other conditions and may happen following a large diversity of mechanisms. Both oncogenic and tumor suppressor mutations can lead to an increase of ROS. In this chapter, I review how ROS are produced and detoxified and how ROS can damage DNA leading to the genomic instability featured in cancers.



中文翻译:

癌症中的活性氧和 DNA 损伤反应

与正常细胞相比,癌细胞的活性氧(ROS)水平通常会增加。这种高水平的 ROS 允许激活细胞转化和肿瘤发生发展所必需的不同途径。ROS的增加可能是由于产生的增加或解毒的减少,这两种情况在各种癌症中都有很好的描述。从开始到转移,癌症发展的每一步都涉及氧化应激。ROS 是如何产生的仍然是一个有争议的问题,它可能会随着组织、细胞类型或其他条件的不同而不同,并且可能发生在多种机制之后。致癌和肿瘤抑制突变都可以导致活性氧的增加。在这一章当中,

更新日期:2021-05-03
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