Abstract

High operational costs of modern medical devices and the required specialized, skilled personnel with certifications to operate most medical instrumentation remains a challenge and an impediment to rapid medical diagnosis and clinical analysis. The simplicity, portability, and ease of operation makes Raman spectrometers appealing for rapid medical diagnosis and clinical analysis at an affordable cost. Besides, the combined use of Raman spectroscopy and multivariate analyses has further facilitated effective pattern recognition providing accurate classification, and/or differentiation of biological and clinical samples. This review article highlights recent advances in Raman spectroscopy in medical diagnosis and clinical analysis between January 2018 and December 2020. Recent innovations in the use of Raman spectroscopy for chemical analysis in human specimens are discussed. Applications of Raman spectroscopy in cancer immunotherapy, cancer imaging, and detecting disease biomarkers in clinical samples are further highlighted. The review article highlights recent innovations in the use of Raman spectroscopy for the detection of various pathogens in human specimens. Moreover, recent innovations of combined uses of Raman spectroscopy and multivariate regression analyses for pattern recognition, and/or classification of clinical samples are discussed. Furthermore, insights into the projection in the use of Raman spectroscopy in medical diagnosis and clinical sample analysis are discussed.

摘要

现代医疗设备的高运营成本以及需要获得操作大多数医疗仪器认证的专业技术人员仍然是快速医疗诊断和临床分析的挑战和障碍。拉曼光谱仪的简单性、便携性和易于操作性使拉曼光谱仪以可承受的成本吸引了快速医学诊断和临床分析。此外，拉曼光谱和多元分析的结合使用进一步促进了有效的模式识别，提供了生物和临床样本的准确分类和/或区分。这篇综述文章重点介绍了 2018 年 1 月至 2020 年 12 月期间拉曼光谱在医学诊断和临床分析方面的最新进展。讨论了使用拉曼光谱对人体标本进行化学分析的最新创新。进一步强调了拉曼光谱在癌症免疫治疗、癌症成像和检测临床样本中的疾病生物标志物方面的应用。该评论文章重点介绍了使用拉曼光谱检测人体标本中各种病原体的最新创新。此外，还讨论了结合使用拉曼光谱和多元回归分析进行模式识别和/或临床样本分类的最新创新。此外，还讨论了对拉曼光谱在医学诊断和临床样本分析中使用的预测的见解。并进一步强调了在临床样本中检测疾病生物标志物。该评论文章重点介绍了使用拉曼光谱检测人体标本中各种病原体的最新创新。此外，还讨论了结合使用拉曼光谱和多元回归分析进行模式识别和/或临床样本分类的最新创新。此外，还讨论了对拉曼光谱在医学诊断和临床样本分析中使用的预测的见解。并进一步强调了在临床样本中检测疾病生物标志物。该评论文章重点介绍了使用拉曼光谱检测人体标本中各种病原体的最新创新。此外，还讨论了结合使用拉曼光谱和多元回归分析进行模式识别和/或临床样本分类的最新创新。此外，还讨论了对拉曼光谱在医学诊断和临床样本分析中使用的预测的见解。讨论了结合使用拉曼光谱和多元回归分析进行模式识别和/或临床样本分类的最新创新。此外，还讨论了对拉曼光谱在医学诊断和临床样本分析中使用的预测的见解。讨论了结合使用拉曼光谱和多元回归分析进行模式识别和/或临床样本分类的最新创新。此外，还讨论了对拉曼光谱在医学诊断和临床样本分析中使用的预测的见解。