当前位置: X-MOL 学术Aging Neuropsychol. Cognit. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Association of cardiometabolic health factors with age-related executive function and episodic memory
Aging, Neuropsychology, and Cognition ( IF 2.102 ) Pub Date : 2021-05-02 , DOI: 10.1080/13825585.2021.1915948
Judith D Lobo 1 , Zachary T Goodman 2 , Jennifer A Schmaus 2 , Lucina Q Uddin 2 , Roger C McIntosh 2
Affiliation  

ABSTRACT

Although decline of cognitive abilities in late life is regarded as a common facet of aging, there is inter-individual variability in this decline. Possible contributors are cardiometabolic risk factors associated with cerebrovascular dysfunction, but a dearth in unifying health-cognition models confound exactly how these risk factors mediate age-related changes in executive function (EF) and episodic memory. This study investigated the indirect effect of age on these cognitive abilities via cardiometabolic risk factors using a structural equation modeling approach. Participants included 738 adults (64% female) ranging from 21 to 85 years of age (M = 47.47, SD = 18.28). An exploratory factor analysis was applied to an EF battery yielding a two-factor solution, consisting of inhibition and cognitive flexibility, that showed acceptable fit (χ2(48) = 101.84, p < .001, CFI = .980, RMSEA = .039, SRMR = .035). The EF latent factors were then included in a confirmatory factor analysis exploring the indirect role of age on episodic memory and EF via blood pressure, cholesterol, triglycerides and body mass index. The theoretical model demonstrated acceptable fit, χ2(108) = 204.071, p < .001, CFI = .972, RMSEA = .035, SRMR = .035. Blood pressure was associated with lower cognitive flexibility (β = −.20, p < .001) and there was a significant indirect effect of age on episodic memory through cognitive flexibility (β = .07, p = .021). Results support the “Executive Decline Hypothesis” of age-related episodic memory decline and specifically implicate lower blood pressure control and cognitive flexibility in these changes.



中文翻译:

心脏代谢健康因素与年龄相关执行功能和情景记忆的关联

摘要

尽管晚年认知能力下降被认为是衰老的一个常见问题,但这种下降存在个体差异。可能的原因是与脑血管功能障碍相关的心脏代谢危险因素,但缺乏统一的健康认知模型,导致这些危险因素如何介导与年龄相关的执行功能(EF)和情景记忆变化。本研究采用结构方程建模方法,研究了年龄通过心脏代谢危险因素对这些认知能力的间接影响。参与者包括 738 名成年人(64% 为女性),年龄从 21 岁到 85 岁不等(M = 47.47,SD = 18.28)。对 EF 电池进行探索性因素分析,产生双因素解决方案,包括抑制和认知灵活性,显示出可接受的拟合度 (χ2(48) = 101.84,p < .001,CFI = .980,RMSEA = .039 ,SRMR = .035)。然后将 EF 潜在因素纳入验证性因素分析,探讨年龄通过血压、胆固醇、甘油三酯和体重指数对情景记忆和 EF 的间接作用。理论模型显示拟合效果可接受,χ2(108) = 204.071,p < .001,CFI = .972,RMSEA = .035,SRMR = .035。血压与较低的认知灵活性相关(β = -.20,p < .001),并且年龄通过认知灵活性对情景记忆产生显着的间接影响(β = .07,p = .021)。结果支持与年龄相关的情景记忆衰退的“执行力衰退假说”,并特别暗示这些变化中血压控制和认知灵活性降低。

更新日期:2021-05-02
down
wechat
bug