To explore corneal biomechanical changes, identify related factors and determine early indicators of keratoconus (KC) development risk in allergic conjunctivitis (AC) patients. A total of 50 patients, including 20 eyes without AC and 30 eyes with AC were enrolled in this study. All patients underwent a complete ocular examination, including evaluations of clinical manifestations of AC, corneal tomography and densitometry by Pentacam, corneal biomechanics by Corvis ST, and corneal and epithelial thickness mapping by RTvue optical coherence tomography (OCT). The index of surface variance (ISV), index of vertical asymmetry (IVA), keratoconus index (KI), index of height decentration (IHD) and Belin/Ambrosio enhanced ectasia total deviation index (BAD-D) were significantly higher in the AC group than in the non-allergic conjunctivitis (NAC) group (P < 0.05). The tomography and biomechanical index (TBI) was also significantly higher in the AC group (P = 0.04). The average epithelial thickness in the 2–7 mm annulus was significantly thinner in the AC group than in the NAC group (P < 0.05). The average densitometry of the total cornea and the anterior layer were higher in the AC group than in the NAC group (P < 0.001). The ISV, IVA, KI, IHD and BAD-D were significantly correlated with the TBI and changes in corneal epithelial thickness in AC patients (P < 0.05). The changes in epithelial thickness were closely related to the eye rubbing frequency and allergic sign scores (P < 0.05). AC patients should be advised to routinely undergo corneal tomographic and biomechanical measurements, and the TBI could be used as an indicator of KC development risk in AC patients. Corneal Biomechanical Changes of Allergic Conjunctivitis, NCT04299399 . Registered March 3, 2020 - Retrospectively registered.

中文翻译：

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过敏性结膜炎的角膜生物力学变化

为了探讨角膜生物力学变化，确定相关因素并确定变应性结膜炎（AC）患者圆锥角膜（KC）发育风险的早期指标。本研究共纳入50例患者，包括20眼无AC眼和30眼AC眼。所有患者均接受了全面的眼科检查，包括评估AC的临床表现，通过Pentacam评估角膜断层扫描和密度测定，通过Corvis ST评估角膜生物力学以及通过RTvue光学相干层析成像（OCT）评估角膜和上皮厚度。表面变化指数（ISV），垂直不对称指数（IVA），圆锥角膜指数（KI），AC组的身高下降指数（IHD）和贝林/ Ambrosio增强的扩张总偏差指数（BAD-D）显着高于非过敏性结膜炎（NAC）组（P <0.05）。AC组的断层扫描和生物力学指数（TBI）也显着更高（P = 0.04）。AC组的2-7 mm环的平均上皮厚度比NAC组的要薄得多（P <0.05）。AC组的总角膜和前层平均密度高于NAC组（P <0.001）。IAC，IVA，KI，IHD和BAD-D与AC患者的TBI和角膜上皮厚度的变化显着相关（P <0.05）。上皮厚度的变化与揉搓频率和过敏体征评分密切相关（P <0.05）。应建议AC患者常规进行角膜断层扫描和生物力学测量，而TBI可用作AC患者KC发生风险的指标。变应性结膜炎的角膜生物力学变化，NCT04299399。2020年3月3日注册-追溯注册。