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Neural reward circuit dysfunction as a risk factor for bipolar spectrum disorders and substance use disorders: A review and integration
Clinical Psychology Review ( IF 12.8 ) Pub Date : 2021-05-03 , DOI: 10.1016/j.cpr.2021.102035
Corinne P Bart 1 , Madison K Titone 1 , Tommy H Ng 1 , Robin Nusslock 2 , Lauren B Alloy 1
Affiliation  

Bipolar spectrum disorders (BSDs) and substance use disorders (SUDs) are associated with neural reward dysfunction. However, it is unclear what pattern of neural reward function underlies pre-existing vulnerability to BSDs and SUDs, or whether neural reward function explains their high co-occurrence. The current paper provides an overview of the separate literatures on neural reward sensitivity in BSDs and SUDs. We provide a systematic review of 35 studies relevant to identifying neural reward function vulnerability to BSDs and SUDs. These studies include those examining neural reward processing on a monetary reward task with prospective designs predicting initial onset of SUDs, familial risk studies that examine unaffected offspring or first-degree relatives of family members with BSDs or SUDs, and studies that examine individuals with BSDs or SUDs who are not currently in an episode of the disorder. Findings from the review highlight that aberrant responding and connectivity across neural regions associated with reward and cognitive control confers risk for the development of BSDs and SUDs. Discussion focuses on limitations of the extant literature. We conclude with an integration and theoretical model for understanding how aberrant neural reward responding may constitute a vulnerability to the development of both BSDs and SUDs.



中文翻译:

神经奖赏回路功能障碍作为双相谱系障碍和物质使用障碍的危险因素:回顾和整合

双相谱系障碍 (BSD) 和物质使用障碍 (SUD) 与神经奖赏功能障碍有关。然而,尚不清楚哪种神经奖励功能模式是预先存在的 BSD 和 SUD 脆弱性的基础,或者神经奖励功能是否解释了它们的高共现性。本论文概述了关于 BSD 和 SUD 中神经奖励敏感性的单独文献。我们对 35 项与识别 BSD 和 SUD 的神经奖励功能脆弱性相关的研究进行了系统评价。这些研究包括那些检查金钱奖励任务的神经奖励处理,前瞻性设计预测 SUD 的初始发作,检查未受影响的后代或患有 BSD 或 SUD 的家庭成员的一级亲属的家庭风险研究,以及检查目前未出现疾病发作的 BSD 或 SUD 患者的研究。审查结果强调,与奖励和认知控制相关的神经区域的异常反应和连通性会给 BSD 和 SUD 的发展带来风险。讨论的重点是现存文献的局限性。我们总结了一个整合和理论模型,以了解异常的神经奖励反应如何构成 BSD 和 SUD 发展的脆弱性。

更新日期:2021-05-19
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