Infectious SARS-CoV-2 can be recovered from the oral cavities and saliva of COVID-19 patients with potential implications for disease transmission. Reducing viral load in patient saliva using antiviral mouthwashes may therefore have a role as a control measure in limiting virus spread, particularly in dental settings. Here, the efficacy of SARS-CoV-2 inactivation by seven commercially available mouthwashes with a range of active ingredients were evaluated in vitro. We demonstrate ≥4.1 to ≥5.5 log10 reduction in SARS-CoV-2 titre following a 1 min treatment with commercially available mouthwashes containing 0.01–0.02 % stabilised hypochlorous acid or 0.58 % povidone iodine, and non-specialist mouthwashes with both alcohol-based and alcohol-free formulations designed for home use. In contrast, products containing 1.5 % hydrogen peroxide or 0.2 % chlorhexidine gluconate were ineffective against SARS-CoV-2 in these tests. This study contributes to the growing body of evidence surrounding virucidal efficacy of mouthwashes/oral rinses against SARS-CoV-2, and has important applications in reducing risk associated with aerosol generating procedures in dentistry and potentially for infection control more widely.

中文翻译：

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通过市售漱口水有效地灭活SARS-CoV-2

传染性SARS-CoV-2可以从COVID-19患者的口腔和唾液中回收，对疾病传播具有潜在影响。因此，使用抗病毒漱口水降低患者唾液中的病毒载量可能在限制病毒传播方面具有控制作用，尤其是在牙科环境中。在此，通过体外评估了七种含有多种活性成分的市售漱口水对SARS-CoV-2灭活的功效。我们证明≥4.1至≥5.5log 10使用市售的含0.01-0.02％稳定次氯酸或0.58％聚维酮碘的漱口水处理1分钟后，SARS-CoV-2滴度降低，以及使用专为家庭设计的含酒精和无酒精配方的非专业漱口水。相反，在这些测试中，含有1.5％过氧化氢或0.2％葡萄糖酸洗必太的产品对SARS-CoV-2无效。这项研究有助于增加漱口水/口服漱口水对SARS-CoV-2的杀病毒功效的证据，并且在降低与牙科用气雾剂产生程序相关的风险以及可能更广泛地控制感染方面具有重要的应用价值。