Background: Insulin resistance is a pathophysiological condition associated with diabetes and cardiometabolic diseases that is characterized by a diminished tissue response to insulin action. Our understanding of this complex phenomenon and its role in the pathogenesis of cardiometabolic diseases is rooted in the discovery of insulin, its isolation and purification, and the challenges encountered with its therapeutic use. Summary: In this historical perspective, we explore the evolution of the term “insulin resistance” and demonstrate how advances in insulin and glucose analytics contributed to the recognition and validation of this metabolic entity. We identify primary discoveries which were pivotal in expanding our knowledge of insulin resistance, the challenges in measurement and interpretation, contemporary techniques, and areas of future exploration. Key Message: Measurements of insulin resistance are important tools for defining and treating cardiometabolic diseases. Accurate quantification of this pathophysiological entity requires careful consideration of the assumptions and pitfalls of the methodological techniques and the historical and clinical context when interpreting and applying the results.
Horm Res Paediatr

中文翻译：

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测量人体胰岛素抵抗

背景：胰岛素抵抗是一种与糖尿病和心脏代谢疾病相关的病理生理状况，其特征是组织对胰岛素作用的反应减弱。我们对这种复杂现象及其在心脏代谢疾病发病机制中的作用的理解植根于胰岛素的发现、分离和纯化以及其治疗用途所遇到的挑战。概括：从这个历史角度来看，我们探索了“胰岛素抵抗”一词的演变，并展示了胰岛素和葡萄糖分析的进步如何促进了这一代谢实体的识别和验证。我们确定了对扩展我们对胰岛素抵抗、测量和解释方面的挑战、当代技术以及未来探索领域的了解至关重要的主要发现。关键信息：胰岛素抵抗的测量是定义和治疗心脏代谢疾病的重要工具。在解释和应用结果时，对这种病理生理实体的准确量化需要仔细考虑方法学技术的假设和陷阱以及历史和临床背景。
儿科研究