Abstract

Nucleoli, the largest subnuclear compartments, are formed around arrays of ribosomal gene repeats transcribed by RNA polymerase I. The primary function of nucleoli is ribosome biogenesis. Specific DNA damage response mechanisms exist to maintain the genomic stability of ribosomal repeats. Here, we provide a snapshot of our current understanding of processes involved in nucleolar DNA damage response. We discuss structure and function of ribosomal repeats, techniques developed for studying DNA damage response in nucleoli, as well as molecular mechanisms of DNA damage-induced repression of nucleolar transcription and nucleoli reorganization.

中文翻译：

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核仁中的DNA损伤反应

摘要

核仁是最大的亚核区室，由RNA聚合酶I转录的核糖体基因重复序列周围形成。核仁的主要功能是核糖体的生物发生。存在特定的DNA损伤反应机制，以维持核糖体重复序列的基因组稳定性。在此，我们简要介绍了我们对核仁DNA损伤反应所涉及过程的当前了解。我们讨论核糖体重复序列的结构和功能，研究核仁中DNA损伤反应的技术，以及DNA损伤诱导的核仁转录和核仁重组的分子机制。