Bacterial infections result in hundreds of million cases of severe illness annually worldwide. Rapidly increasing drug resistance of pathogens further aggravates this threat to human health and warrants the search for effective broad-spectrum antibacterial agents. Silver metal has a long history of application in human medicine and healthcare. In ancient times, silver was employed as a disinfectant for water purification and storage while it is still being used as an antimicrobial ingredient in some nanotechnology-based products. Encapsulation of antimicrobial substances such as silver nanoparticles in nanoliposomes could provide protection and targeting for the encapsulated or entrapped material. Nanoliposomes are biocompatible and biodegradable drug delivery systems with the ability to encapsulate both lipid-soluble and water-soluble compounds, as well as metal ions. Furthermore, nanoliposomes have been shown to be able to deliver encapsulated agents to target bacteria in vitro as well as in vivo. In this review, we present the use of nanoliposome-encapsulated silver nanoparticles as an efficient system for antibacterial applications.

全世界每年细菌感染导致数亿例严重疾病。快速增长的病原体耐药性进一步加剧了对人类健康的威胁，并有必要寻找有效的广谱抗菌剂。金属银在人类医学和医疗保健中的应用历史悠久。在远古时代，银被用作水净化和储存的消毒剂，而在某些基于纳米技术的产品中，银仍被用作抗菌成分。纳米脂质体中抗微生物物质（如银纳米颗粒）的封装可为被封装或截留的材料提供保护和靶向。纳米脂质体是具有生物相容性且可生物降解的药物递送系统，能够封装脂溶性和水溶性化合物，以及金属离子。此外，已经显示出纳米脂质体能够在体外以及体内将包封的试剂递送至靶细菌。在这篇综述中，我们介绍了纳米脂质体包裹的银纳米颗粒作为抗菌应用的有效系统的使用。