Abstract

Haloperidol is a highly potent, first-generation antipsychotic drug used for the treatment of several disorders. It exerts its antipsychotic effect through the strong antagonism in the dopamine D2 receptor. Effective analytical procedures are required for clinical and pharmaceutical studies. In this review, a variety of analytical techniques and associated methodologies for the determination of haloperidol are detailed including spectrophotometry, spectrofluorimetric, nuclear magnetic resonance spectroscopy, thin layer chromatography, electrophoresis, liquid chromatography, and gas chromatography. HPLC is the most widely used technique.

中文翻译：

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氟哌啶醇及其组合在药物剂型和生物基质中的分析测定

摘要

氟哌啶醇是用于治疗多种疾病的高效第一代抗精神病药。它通过对多巴胺D2受体的强烈拮抗作用发挥抗精神病作用。临床和药物研究需要有效的分析程序。在这篇综述中，详细介绍了测定氟哌啶醇的各种分析技术和相关方法，包括分光光度法，荧光光谱法，核磁共振波谱法，薄层色谱法，电泳，液相色谱法和气相色谱法。HPLC是应用最广泛的技术。