In the preclinical stage of the Alzheimer’s disease (AD) continuum, subjects report subjective memory complaints (SMCs), although with the absence of any objective decline, and have a higher risk of progressing to dementia than the general population. Early identification of this stage therefore constitutes a major focus of current AD research, to enable early intervention. In this study, healthy adult participants with high and low SMCs (HSMCs and LSMCs) performed a Go/NoGo task during electroencephalogram (EEG) recording. Relative to LSMC participants, HSMC participants performed the task slower (longer reaction times) and showed changes in the event-related potential (ERP) components associated with response preparation (lower readiness potential -RP- amplitude in the Go condition), and also related to response inhibition processes (lower N2-P3 amplitude in the NoGo condition). In addition, HSMC participants showed lower Go-N2 and NoGo-N2 peak-to-baseline amplitudes, however these results seem to be influenced by a negative tendency overlapping stimulus-related waveforms. The declines observed in this study are mostly consistent with those observed in aMCI participants, supporting the notion of the AD continuum regarding SMC state.

在阿尔茨海默病 (AD) 连续体的临床前阶段，受试者报告主观记忆不适 (SMC)，尽管没有任何客观下降，并且与一般人群相比，发展为痴呆的风险更高。因此，对这一阶段的早期识别构成了当前 AD 研究的主要焦点，以实现早期干预。在这项研究中，具有高和低 SMC（HSMC 和 LSMC）的健康成年参与者在脑电图（EEG）记录期间执行了 Go/NoGo 任务。相对于 LSMC 参与者，HSMC 参与者执行任务的速度较慢（反应时间较长），并表现出与响应准备相关的事件相关电位 (ERP) 组件的变化（在 Go 条件下较低的准备电位 -RP- 幅度），并且还与反应抑制过程有关（NoGo 条件下 N2-P3 幅度较低）。此外，HSMC 参与者显示出较低的 Go-N2 和 NoGo-N2 峰基线幅度，但这些结果似乎受到与刺激相关波形重叠的负趋势的影响。本研究中观察到的下降与在 aMCI 参与者中观察到的下降基本一致，这支持了关于 SMC 状态的 AD 连续体的概念。