CD8+ T cells actively penetrate hepatocytes via the CD44/p-ERM/F-actin pathway in autoimmune hepatitis,Journal of Digestive Diseases

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CD8+ T cells actively penetrate hepatocytes via the CD44/p-ERM/F-actin pathway in autoimmune hepatitis
Journal of Digestive Diseases ( IF 3.5 ) Pub Date : 2021-04-29 , DOI: 10.1111/1751-2980.12995
Ju Bo Liang ₁ , Yong Chen ₁ , Rui Ling Chen ₁ , Yi Kang Li ₁ , Bo Li ₁ , Zheng Rui You ₁ , You Li ₁ , Jun Zhang ₁ , Bing Yuan Huang ₁ , Yi Ran Wei ₁ , Zhu Wan Lyu ₁ , Min Lian ₁ , Xiao Xiao ₁ , Qi Xia Wang ₁ , Ru Qi Tang ₁ , Jing Yuan Fang ₁ , Xiao Yu Chen ₁ , Xiong Ma ₁ , Qi Miao ₁

Affiliation

Emperipolesis is a pathological feature for the diagnosis of autoimmune hepatitis (AIH). We have previously found that CD8⁺ T cells participated in the emperipolesis in AIH. In this study we aimed to clarify the characteristics and molecular mechanisms of emperipolesis in patients with AIH in vitro and in mice with α-Galactosylceramide (α-GalCer)-induced acute hepatitis.

中文翻译：

CD8+ T 细胞在自身免疫性肝炎中通过 CD44/p-ERM/F-肌动蛋白通路主动穿透肝细胞

Emperipolesis 是诊断自身免疫性肝炎 (AIH) 的病理特征。我们之前已经发现 CD8 ⁺ T 细胞参与了 AIH 的周向运动。在本研究中，我们旨在阐明 AIH 患者体外和 α-半乳糖苷神经酰胺 (α-GalCer) 诱导的急性肝炎小鼠经皮运动的特征和分子机制。

更新日期：2021-06-18

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