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Silver nanoparticles synthesized using leaf extract of Azadirachta indica exhibit enhanced antimicrobial efficacy than the chemically synthesized nanoparticles: A comparative study
Science Progress ( IF 2.1 ) Pub Date : 2021-04-29 , DOI: 10.1177/00368504211012159
Kashan Khan 1 , Saleem Javed 1
Affiliation  

A wide variety of methods have synthesized silver nanoparticles (Ag-NPs) in the recent past; however, biological methods have attracted much attention over the traditional chemical synthesis method due to being non-hazardous and eco-friendly. Here, a detailed and systemic study was performed to compare two different synthesis routes for Ag-NPs, that is, the chemical and the biological; their possible outcomes have also been described. Ag-NPs were synthesized chemically (cAg-NPs) using a chemical reductant and biologically (bAg-NPs) by using aqueous leaf extract of Azadirachta indica (neem). The synthesized nanoparticles were characterized using UV-visible spectrophotometry, FT-IR, EDX, and TEM. The average particle sizes (APS) of cAg-NPs were found to be 8 and 13 nm and of bAg-NPs to be 19 and 43 nm under different AgNO3 concentrations. The antimicrobial tests of differently sized NPs were performed against Escherichia coli (Gram −ve) and Staphylococcus aureus (Gram +ve). The results revealed that bAg-NPs of APS 43 nm were highly antimicrobial against both the tested bacterial stains followed by cAg-NPs of 8 nm. We found the effect of cAg-NPs to be size-dependent, whereas bAg-NPs showed a more significant antimicrobial effect than cAg-NPs.



中文翻译:

使用印楝叶提取物合成的银纳米粒子比化学合成的纳米粒子表现出更强的抗菌功效:一项比较研究

近年来,合成银纳米颗粒(Ag-NP)的方法多种多样;然而,生物方法由于无毒且环保,比传统的化学合成方法更受关注。在此,我们进行了详细、系统的研究,比较了两种不同的Ag-NPs合成路线,即化学法和生物法;还描述了其可能的结果。Ag-NPs 使用化学还原剂进行化学合成 (cAg-NPs),并使用印楝(neem) 的水叶提取物进行生物合成 (bAg-NPs)。使用紫外-可见分光光度法、FT-IR、EDX 和 TEM 对合成的纳米颗粒进行了表征。在不同AgNO 3浓度下,cAg-NPs的平均粒径(APS)为8和13 nm,bAg-NPs的平均粒径为19和43 nm 。对不同大小的纳米颗粒进行了针对大肠杆菌(Gram -ve)和金黄色葡萄球菌(Gram +ve)的抗菌测试。结果显示,APS 43 nm 的 bAg-NP 对两种测试的细菌污渍均具有高度抗菌作用,其次是 8 nm 的 cAg-NP。我们发现 cAg-NPs 的效果依赖于尺寸,而 bAg-NPs 比 cAg-NPs 表现出更显着的抗菌效果。

更新日期:2021-04-30
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