Cyclodextrin-based polymers (CDPs) are amphiphilic macromolecules owing to their unique structure and the presence of multiple hydroxyl groups. These polymers have become increasingly popular in applications ranging from biomedicine to environmental science. In this review, four types of CDPs are distinguished based on their structural characteristics: cyclodextrin-based polyrotaxanes, grafted cyclodextrin polymers, cross-linked cyclodextrin polymers, and cyclodextrin-originated star/multi-arm polymers. The discussion includes the syntheses and properties of several derivatives of CDPs. In addition to low toxicity, good bioavailability and biodegradability, and the feasibility of inclusion complexation and chemical modification of cyclodextrins, these polymers have prominent advantages, such as stimuli responsiveness and the ability to form well-defined aggregated nanostructures, which make them promising candidates for applications related to controlled and targeted drug delivery. In this review, we have highlighted the evolution, unique types, and properties of various CDPs, which are core aspects that differ from previously published reviews. Additionally, the synergistic effect of cyclodextrin and cross-linking monomers, as well as their use as drug carriers over the past decade, have been emphasized.

基于环糊精的聚合物（CDP）由于其独特的结构和多个羟基的存在而成为两亲性大分子。这些聚合物在从生物医学到环境科学的应用中越来越受欢迎。在这篇综述中，基于其结构特征区分了四种CDP：基于环糊精的聚轮烷，接枝的环糊精聚合物，交联的环糊精聚合物和源自环糊精的星形/多臂聚合物。讨论包括CDP的几种衍生物的合成和性质。除了低毒性，良好的生物利用度和生物降解性以及环糊精的包合物络合和化学修饰的可行性外，这些聚合物还具有显着的优势，例如刺激反应能力和形成定义明确的聚集纳米结构的能力，这使其成为与受控和靶向药物输送有关的应用的有希望的候选者。在这篇评论中，我们重点介绍了各种CDP的演变，独特类型和属性，这些是与以前发布的评论不同的核心方面。另外，在过去的十年中，已经强调了环糊精和交联单体的协同作用以及它们作为药物载体的用途。