The immune response during T spiralis infection is characterized by an increase in eosinophils and mast cells, as well as Th2 cytokine production, such as interleukin (IL)-4, IL-10 and IL-13, promoting T spiralis expulsion from the host. However, this response damages the host, favouring the parasite survival. In the search for new pharmacological strategies that protect against T spiralis infection, a recent study showed that treatment with resiniferatoxin (RTX) modulates the Th1 cytokines production, reducing muscle parasite burden.

中文翻译：

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树脂毒素通过 Th2 免疫反应调节促进旋毛虫感染大鼠的成虫排出

螺旋体螺旋体感染期间的免疫反应的特点是嗜酸性粒细胞和肥大细胞增加，以及 Th2 细胞因子的产生，如白细胞介素 (IL)-4、IL-10 和 IL-13，促进螺旋体从宿主中排出。然而，这种反应会损害宿主，有利于寄生虫的生存。在寻找防止螺旋线虫感染的新药理学策略时，最近的一项研究表明，用树脂毒素 (RTX) 治疗可调节 Th1 细胞因子的产生，从而减少肌肉寄生虫负担。