Despite all the other cells that have the potential to prevent cancer development and metastasis through tumour suppressor proteins, cancer cells can upregulate the ubiquitin–proteasome system (UPS) by which they can degrade tumour suppressor proteins and avoid apoptosis. This system plays an extensive role in cell regulation organized in two steps. Each step has an important role in controlling cancer. This demonstrates the importance of understanding UPS inhibitors and improving these inhibitors to foster a new hope in cancer therapy. UPS inhibitors, as less invasive chemotherapy drugs, are increasingly used to alleviate symptoms of various cancers in malignant states. Despite their success in reducing the development of cancer with the lowest side effects, thus far, an appropriate inhibitor that can effectively inactivate this system with the least drug resistance has not yet been fully investigated. A fundamental understanding of the system is necessary to fully elucidate its role in causing/controlling cancer. In this review, we first comprehensively investigate this system, and then each step containing ubiquitination and protein degradation as well as their inhibitors are discussed. Ultimately, its advantages and disadvantages and some perspectives for improving the efficiency of these inhibitors are discussed.

尽管所有其他细胞都有可能通过抑癌蛋白来预防癌症的发展和转移，但癌细胞可以上调泛素-蛋白酶体系统 (UPS)，从而降解抑癌蛋白并避免细胞凋亡。该系统在分两步组织的细胞调节中起着广泛的作用。每个步骤在控制癌症方面都具有重要作用。这证明了了解 UPS 抑制剂并改进这些抑制剂以培育癌症治疗新希望的重要性。UPS抑制剂作为微创化疗药物，越来越多地用于缓解各种恶性肿瘤的症状。尽管他们成功地以最低的副作用减少了癌症的发展，但到目前为止，尚未充分研究能够以最少的耐药性有效地使该系统失活的适当抑制剂。对该系统有基本的了解对于充分阐明其在引起/控制癌症中的作用是必要的。在这篇综述中，我们首先全面研究了这个系统，然后讨论了包含泛素化和蛋白质降解的每个步骤及其抑制剂。最后，讨论了其优点和缺点以及提高这些抑制剂效率的一些观点。然后讨论了包含泛素化和蛋白质降解及其抑制剂的每个步骤。最后，讨论了其优点和缺点以及提高这些抑制剂效率的一些观点。然后讨论了包含泛素化和蛋白质降解及其抑制剂的每个步骤。最后，讨论了其优点和缺点以及提高这些抑制剂效率的一些观点。