In the last decade, microfluidics has opened new avenues for the synthesis of nanomaterials. However, the adoption of this production technique has been limited to a few high-value, low-production-volume organic nanoparticles. While there are several technical factors that can be attributed to this slow adoption, an important aspect to consider is the lack of a unified platform capable of producing a wide range of nanomaterials. In this work, we highlight a micro-mixing platform that can manufacture both organic and in-organic nanoparticles over a wide size range (nm-μm). We show that the platform can predictably and reproducibly create size and shape-controlled formulations with high homogeneity through input flow parameters. We further explore parallelization of this platform and discuss key technical constraints for high-volume production. We believe that the platform presented in this work can accelerate the adoption of nanomaterials relevant to a range of industries that encompass pharmaceutics, diagnostics, and cosmeceuticals.

在过去的十年中，微流体为纳米材料的合成开辟了新的途径。然而，这种生产技术的采用仅限于少数高价值、低产量的有机纳米粒子。虽然有几个技术因素可归因于这种缓慢的采用，但需要考虑的一个重要方面是缺乏能够生产各种纳米材料的统一平台。在这项工作中，我们重点介绍了一种微混合平台，该平台可以制造宽尺寸范围（nm-μm）的有机和无机纳米颗粒。我们表明，该平台可以通过输入流量参数可预测和可重复地创建具有高度均匀性的尺寸和形状控制配方。我们进一步探索了该平台的并行化，并讨论了大批量生产的关键技术限制。