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The contradictory role of androgens in cutaneous and major burn wound healing
Burns & Trauma ( IF 5.3 ) Pub Date : 2021-04-20 , DOI: 10.1093/burnst/tkaa046
Huaikai Shi 1 , Kenny Cheer 1 , Ulla Simanainen 2 , Brian Lesmana 1 , Duncan Ma 1 , Jonathan J Hew 1 , Roxanne J Parungao 1 , Zhe Li 1, 3 , Mark S Cooper 4 , David J Handelsman 2 , Peter K Maitz 1, 3 , Yiwei Wang 1
Affiliation  

Wound healing is a complex process involving four overlapping phases: haemostasis, inflammation, cell recruitment and matrix remodeling. In mouse models, surgical, pharmacological and genetic approaches targeting androgen actions in skin have shown that androgens increase interleukin-6 and tumor necrosis factor-α production and reduce wound re-epithelization and matrix deposition, retarding cutaneous wound healing. Similarly, clinical studies have shown that cutaneous wound healing is slower in men compared to women. However, in major burn injury, which triggers not only local wound-healing processes but also systemic hypermetabolism, the role of androgens is poorly understood. Recent studies have claimed that a synthetic androgen, oxandrolone, increases protein synthesis, improves lean body mass and shortens length of hospital stay. However, the possible mechanisms by which oxandrolone regulates major burn injury have not been reported. In this review, we summarize the current findings on the roles of androgens in cutaneous and major burn wound healing, as well as androgens as a potential therapeutic treatment option for patients with major burn injuries.

中文翻译:

雄激素在皮肤和严重烧伤创面愈合中的矛盾作用

伤口愈合是一个复杂的过程,涉及四个重叠阶段:止血,炎症,细胞募集和基质重塑。在小鼠模型中,针对皮肤中雄激素作用的外科,药理和遗传学方法表明,雄激素会增加白介素6和肿瘤坏死因子-α的产生,并减少伤口的上皮形成和基质沉积,从而延缓皮肤伤口的愈合。同样,临床研究表明,与女性相比,男性的皮肤伤口愈合速度较慢。然而,在严重烧伤中,不仅引发局部伤口愈合过程,而且引发全身性新陈代谢,对雄激素的作用了解甚少。最近的研究声称合成雄激素氧雄酮可增加蛋白质合成,改善瘦体重并缩短住院时间。然而,氧雄龙调节严重烧伤的可能机制尚未见报道。在这篇综述中,我们总结了有关雄激素在皮肤和严重烧伤创面愈合中作用的最新发现,以及雄激素作为重度烧伤患者的潜在治疗选择。
更新日期:2021-04-29
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