Background: With the growing stress on hospitals caused by the COVID-19 pandemic, the need for home-based solutions has become a necessity to support these overwhelmed hospitals. Objective: The goal of this study was to compare two nonpharmacological respiratory treatment methods for home-isolated COVID-19 patients using a newly developed telemanagement health care system. Methods: In this single-blinded randomized clinical trial, 60 patients with stage 1 pneumonia caused by SARS-CoV-2 infection were treated. Group A (n=30) received oxygen therapy with bilevel positive airway pressure (BiPAP) ventilation, and Group B (n=30) received osteopathic manipulative respiratory and physical therapy techniques. Arterial blood gases of PaO2 and PaCO2, pH, vital signs (ie, temperature, respiratory rate, oxygen saturation, heart rate, and blood pressure), and chest computed tomography scans were used for follow-up and for assessment of the course and duration of recovery. Results: Analysis of the results showed a significant difference between the two groups (P<.05), with Group A showing shorter recovery periods than Group B (mean 14.9, SD 1.7 days, and mean 23.9, SD 2.3 days, respectively). Significant differences were also observed between baseline and final readings in all of the outcome measures in both groups (P<.05). Regarding posttreatment satisfaction with our proposed telemanagement health care system, positive responses were given by most of the patients in both groups. Conclusions: It was found that home-based oxygen therapy with BiPAP can be a more effective prophylactic treatment approach than osteopathic manipulative respiratory and physical therapy techniques, as it can impede exacerbation of early-stage COVID-19 pneumonia. Telemanagement health care systems are promising methods to help in the pandemic-related shortage of hospital beds, as they showed reasonable effectiveness and reliability in the monitoring and management of patients with early-stage COVID-19 pneumonia. Trial Registration: ClinicalTrials.gov NCT04368923; https://clinicaltrials.gov/ct2/show/NCT04368923

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中文翻译：

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使用无创正压通气和物理治疗技术氧疗的居家隔离 COVID-19 患者的远程管理：随机临床试验

背景：随着 COVID-19 大流行对医院造成的压力越来越大，对家庭解决方案的需求已成为支持这些不堪重负的医院的必要条件。目的：本研究的目的是比较使用新开发的远程管理医疗保健系统对居家隔离的 COVID-19 患者的两种非药物呼吸治疗方法。方法：在这项单盲随机临床试验中，治疗了 60 名由 SARS-CoV-2 感染引起的 1 期肺炎患者。A组（n=30）接受双水平气道正压通气（BiPAP）氧疗，B组（n=30）接受整骨手法呼吸和物理治疗技术。PaO2 和 PaCO2 的动脉血气、pH、生命体征（即温度、呼吸频率、氧饱和度、心率和血压），胸部计算机断层扫描用于随访和评估恢复过程和持续时间。结果：结果分析显示两组之间存在显着差异（P<.05），A组恢复期短于B组（分别为平均14.9、SD 1.7天和平均23.9、SD 2.3天）。在两组的所有结果测量中，基线读数和最终读数之间也存在显着差异（P<.05）。关于我们提议的远程管理医疗保健系统的治疗后满意度，两组中的大多数患者都给出了积极的回应。结论：发现使用 BiPAP 的家庭氧疗可能是比整骨手法呼吸和物理治疗技术更有效的预防性治疗方法，因为它可以阻止早期 COVID-19 肺炎的恶化。远程管理医疗保健系统是帮助解决与大流行相关的病床短缺的有希望的方法，因为它们在监测和管理早期 COVID-19 肺炎患者方面显示出合理的有效性和可靠性。试验注册：ClinicalTrials.gov NCT04368923；https://clinicaltrials.gov/ct2/show/NCT04368923

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