Graphene oxide (GO) has piqued the interest of both academia and industry owing to its polar and two-dimensional (2D) layered structure. Antibiotic concentrations can be detected with advanced GO composites to reduce the risk of bacterial resistance, which can be done with electrochemical sensors. Herein, we have developed an eco-friendly synthesis approach, one-pot strategy towards Goniothalamus wightii biomass-derived solution preparation of Ag nanoparticle-decorated graphene oxide (GO@AgNPs) composites. As- synthesized GO@AgNPs nanocomposites were analyzed using various analytical tools including Raman, X-ray diffraction (XRD) and field emission scanning electron microscope (FESEM). The Metronidazole (MIZ) determination was then investigated using cycle volumetric and amperometric (i-t) techniques by the GO@AgNPs composites. Prepared composites exhibit a wide-linear range of 0.09 μM to 4.594 mM, low detection limit of 69 nM and a limit of quantification detection of 786 nM. Furthermore, the practical applicability of the prepared GO@AgNPs nanocomposites were examined in pharmaceutical drug Flagyl (500 mg) with satisfactory recovery results.

氧化石墨烯（GO）的极性和二维（2D）分层结构引起了学术界和工业界的兴趣。可以使用先进的GO复合材料检测抗生素浓度，以降低细菌耐药性的风险，这可以通过电化学传感器完成。在这里，我们已经开发了一种生态友好的合成方法，一种针对一壶菌的生物材料衍生的Ag纳米颗粒修饰的氧化石墨烯（GO @ AgNPs）复合材料的溶液制备方法。使用各种分析工具（包括拉曼，X射线衍射（XRD）和场发射扫描电子显微镜（FESEM））分析了合成的GO @ AgNPs纳米复合材料。然后，甲硝唑（MIZ）测定，使用周期和体积安培（研究它）技术由GO @ AgNPs复合材料制成。制备的复合材料显示0.09μM至4.594 mM的宽线性范围，69 nM的低检测限和786 nM的定量检测限。此外，制备的GO @ AgNPs纳米复合材料的实际适用性在药用药物Flagyl（500 mg）中进行了检查，回收率令人满意。