Schiff bases are considered as privileged ligand in coordination chemistry as they easily form stable complexes with most transition metal complexes. In this paper, a novel Schiff-base ligand derived from Curcumin and Semicarbazide (HMHC) and its transition metal [Mn(II), Co(II), Ni(II), Cu(II) and Zn(II)] complexes were synthesized. FT-IR, UV–Vis, NMR, Mass, TG-DTA and ESR spectral techniques were used to confirm the structures of the metal chelates and ligand. The Schiff base behaves as a tridentate ligand with O and N donors and coordinates to metal ion via phenolic oxygens and azomethine nitrogen. The compositions of the ligand and its metal complexes have been established by elemental analysis. Spectral investigations suggested octahedral geometrical arrangement for all the metal(II) complexes, having 2:1 (L:M) stoichiometric ratio of the type [M(HMHC)₂]H₂O. The Schiff base ligand and its metal complexes have been screened for antimicrobial evaluation towards some clinically important microorganisms. Result found that the metal complexes were more active than the ligand. Also anti-inflammatory activity of Schiff base complexes were studied by protein denaturation method and result reveals that Zn(II) complex shows more activity.

Schiff碱在配位化学中被视为特权配体，因为它们容易与大多数过渡金属配合物形成稳定的配合物。本文从姜黄素和氨基脲（HMHC）及其过渡金属[Mn（II），Co（II），Ni（II），Cu（II）和Zn（II）]络合物衍生出一种新型席夫碱配体合成的。FT-IR，UV-Vis，NMR，Mass，TG-DTA和ESR光谱技术用于确认金属螯合物和配体的结构。Schiff碱表现为具有O和N供体的三齿配体，并通过酚氧和偶氮甲碱氮与金属离子配位。配体及其金属配合物的组成已通过元素分析确定。光谱研究表明所有金属（II）配合物的2：8（L：₂ 1 H ₂ O的席夫碱配体及其金属配合物已经被筛选抗微生物评价对某些临床上重要的微生物。结果发现，金属配合物比配体更具活性。还通过蛋白质变性方法研究了席夫碱复合物的抗炎活性，结果表明Zn（II）复合物显示出更多的活性。