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Risk and prognostic factors in perinatal hemorrhagic stroke
Annals of Indian Academy of Neurology ( IF 1.7 ) Pub Date : 2021-03-01 , DOI: 10.4103/aian.aian_580_20 Hüseyin Çaksen 1 , Fatma Tuba Köseoğlu 1 , Ahmet Sami Güven 1 , Hüseyin Altunhan 2 , Mehmet Sinan İyisoy 3 , Saim Açıkgözoğlu 4
Background: Perinatal stroke encompasses a heterogeneous group of focal neurological injuries early in brain development. In this study, we aimed to compare risk and prognostic factors in preterm and term infants with perinatal hemorrhagic stroke (PHS). Patients and Methods: The study includes 66 infants with PHS. The infants were evaluated for demographic characteristics, fetal and maternal risk factors, perinatal events, clinical and neuroimaging findings, complications, and sequales. Results: Of 66 infants with PHS, 44 (66.70%) were preterm and 22 (33.30%) were term infants. Primiparity, mucosal bleeding, and multiple lobes involvement were more common in term infants than preterm infants (P < 0.05); however, respiratory insufficiency, neonatal sepsis, perinatal asphyxia, respiratory distress syndrome, use of invasive mechanical ventilation, use of noninvasive mechanical ventilation, and prolonged hospitalization were more common in preterm infants than term infants (P < 0.05). Eight (12.12%) infants died during infancy period. Small for gestational age and mucosal bleeding were more common in infants who are dead than those alive (P < 0.05). Forty-two (63.63%) infants were followed. Cerebral palsy and/or epilepsy and/or hydrocephalus were diagnosed in 36 (85.72%) infants during follow-up. Conclusion: Our findings showed that PHS was much more common in preterm infants. Mucosal bleeding and multiple lobes involvement were more common in term infants. PHS has high morbidity and mortality rates. Small for gestational age and mucosal bleeding were more common in infants who are dead.
中文翻译：
围产期出血性脑卒中的危险因素和预后因素
背景：围产期中风包括大脑发育早期的一组异质局灶性神经损伤。在这项研究中，我们旨在比较早产儿和足月儿围产期出血性卒中 (PHS) 的风险和预后因素。患者和方法：该研究包括 66 名 PHS 婴儿。对婴儿的人口学特征、胎儿和母体危险因素、围产期事件、临床和神经影像学检查结果、并发症和后遗症进行了评估。结果： 66 例 PHS 婴儿中，44 例（66.70%）为早产儿，22 例（33.30%）为足月儿。初产、黏膜出血和多叶受累在足月儿中比早产儿更常见（P< 0.05); 但早产儿呼吸功能不全、新生儿败血症、围产期窒息、呼吸窘迫综合征、有创机械通气、无创机械通气和住院时间延长在早产儿中的发生率高于足月儿（P < 0.05）。八名（12.12%）婴儿在婴儿期死亡。死婴比活儿更常见小于胎龄儿和黏膜出血（P < 0.05）。对 42 名 (63.63%) 婴儿进行了随访。在随访期间，36 名 (85.72%) 婴儿被诊断为脑瘫和/或癫痫和/或脑积水。结论：我们的研究结果表明，小灵通在早产儿中更为常见。黏膜出血和多叶受累在足月儿中更为常见。PHS 的发病率和死亡率都很高。小于胎龄儿和黏膜出血在死亡婴儿中更为常见。
更新日期：2021-04-29
Annals of Indian Academy of Neurology ( IF 1.7 ) Pub Date : 2021-03-01 , DOI: 10.4103/aian.aian_580_20 Hüseyin Çaksen 1 , Fatma Tuba Köseoğlu 1 , Ahmet Sami Güven 1 , Hüseyin Altunhan 2 , Mehmet Sinan İyisoy 3 , Saim Açıkgözoğlu 4
Affiliation
Background: Perinatal stroke encompasses a heterogeneous group of focal neurological injuries early in brain development. In this study, we aimed to compare risk and prognostic factors in preterm and term infants with perinatal hemorrhagic stroke (PHS). Patients and Methods: The study includes 66 infants with PHS. The infants were evaluated for demographic characteristics, fetal and maternal risk factors, perinatal events, clinical and neuroimaging findings, complications, and sequales. Results: Of 66 infants with PHS, 44 (66.70%) were preterm and 22 (33.30%) were term infants. Primiparity, mucosal bleeding, and multiple lobes involvement were more common in term infants than preterm infants (P < 0.05); however, respiratory insufficiency, neonatal sepsis, perinatal asphyxia, respiratory distress syndrome, use of invasive mechanical ventilation, use of noninvasive mechanical ventilation, and prolonged hospitalization were more common in preterm infants than term infants (P < 0.05). Eight (12.12%) infants died during infancy period. Small for gestational age and mucosal bleeding were more common in infants who are dead than those alive (P < 0.05). Forty-two (63.63%) infants were followed. Cerebral palsy and/or epilepsy and/or hydrocephalus were diagnosed in 36 (85.72%) infants during follow-up. Conclusion: Our findings showed that PHS was much more common in preterm infants. Mucosal bleeding and multiple lobes involvement were more common in term infants. PHS has high morbidity and mortality rates. Small for gestational age and mucosal bleeding were more common in infants who are dead.
中文翻译：
围产期出血性脑卒中的危险因素和预后因素
背景：围产期中风包括大脑发育早期的一组异质局灶性神经损伤。在这项研究中，我们旨在比较早产儿和足月儿围产期出血性卒中 (PHS) 的风险和预后因素。患者和方法：该研究包括 66 名 PHS 婴儿。对婴儿的人口学特征、胎儿和母体危险因素、围产期事件、临床和神经影像学检查结果、并发症和后遗症进行了评估。结果： 66 例 PHS 婴儿中，44 例（66.70%）为早产儿，22 例（33.30%）为足月儿。初产、黏膜出血和多叶受累在足月儿中比早产儿更常见（P< 0.05); 但早产儿呼吸功能不全、新生儿败血症、围产期窒息、呼吸窘迫综合征、有创机械通气、无创机械通气和住院时间延长在早产儿中的发生率高于足月儿（P < 0.05）。八名（12.12%）婴儿在婴儿期死亡。死婴比活儿更常见小于胎龄儿和黏膜出血（P < 0.05）。对 42 名 (63.63%) 婴儿进行了随访。在随访期间，36 名 (85.72%) 婴儿被诊断为脑瘫和/或癫痫和/或脑积水。结论：我们的研究结果表明，小灵通在早产儿中更为常见。黏膜出血和多叶受累在足月儿中更为常见。PHS 的发病率和死亡率都很高。小于胎龄儿和黏膜出血在死亡婴儿中更为常见。
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