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3D printing 18F radioactive phantoms for PET imaging
EJNMMI Physics ( IF 4 ) Pub Date : 2021-04-28 , DOI: 10.1186/s40658-021-00383-6
Daniel Gillett , Daniel Marsden , Safia Ballout , Bala Attili , Nick Bird , Sarah Heard , Mark Gurnell , Iosif A. Mendichovszky , Luigi Aloj

Phantoms are routinely used in molecular imaging to assess scanner performance. However, traditional phantoms with fillable shapes do not replicate human anatomy. 3D-printed phantoms have overcome this by creating phantoms which replicate human anatomy which can be filled with radioactive material. The problem with these is that small objects suffer to a greater extent than larger objects from the effects of inactive walls, and therefore, phantoms without these are desirable. The purpose of this study was to explore the feasibility of creating resin-based 3D-printed phantoms using 18F. Radioactive resin was created using an emulsion of printer resin and 18F-FDG. A series of test objects were printed including twenty identical cylinders, ten spheres with increasing diameters (2 to 20 mm), and a double helix. Radioactive concentration uniformity, printing accuracy and the amount of leaching were assessed. Creating radioactive resin was simple and effective. The radioactive concentration was uniform among identical objects; the CoV of the signal was 0.7% using a gamma counter. The printed cylinders and spheres were found to be within 4% of the model dimensions. A double helix was successfully printed as a test for the printer and appeared as expected on the PET scanner. The amount of radioactivity leached into the water was measurable (0.72%) but not visible above background on the imaging. Creating an 18F radioactive resin emulsion is a simple and effective way to create accurate and complex phantoms without inactive walls. This technique could be used to print clinically realistic phantoms. However, they are single use and cannot be made hollow without an exit hole. Also, there is a small amount of leaching of the radioactivity to take into consideration.

中文翻译:

用于PET成像的3D打印18 F放射性体模

幻影通常用于分子成像中,以评估扫描仪的性能。但是,具有可填充形状的传统体模不能复制人体解剖结构。3D打印的幻影通过创建复制人体解剖结构的幻影克服了这一问题,人体可以充满放射性物质。这些问题在于,小物体比大物体受不活动的墙的影响更大,因此,没有这些的幻影是理想的。这项研究的目的是探索使用18F创建基于树脂的3D打印体模的可行性。使用打印机树脂和18F-FDG的乳液制成放射性树脂。打印了一系列测试对象,包括二十个相同的圆柱体,十个直径增加(2至20 mm)的球体和双螺旋线。放射性浓度均匀性 评估印刷精度和浸出量。创建放射性树脂既简单又有效。相同物体之间的放射性浓度是均匀的。使用伽玛计数器,信号的CoV为0.7%。发现印刷的圆柱体和球体在模型尺寸的4%之内。成功地打印了一个双螺旋线,作为对打印机的测试,并在PET扫描仪上按预期出现了。浸入水中的放射性量是可测量的(0.72%),但在成像本底以上看不见。制作18F放射性树脂乳液是一种简单而有效的方法,可以在没有惰性壁的情况下创建准确而复杂的体模。该技术可用于打印临床上逼真的幻像。但是,它们是一次性的,没有出口就不能做成空心的。还,
更新日期:2021-04-29
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