Astroblastoma is an extremely rare brain tumor that has recently attracted attention owing to its association with MN1 gene alteration. However, its long-term clinical course remains unclear. We report a late recurrence of MN1-altered astroblastoma with unique pathological findings. A 24-year-old woman presented with seizures due to a left frontal lobe tumor. Gross total resection (GTR) was achieved, and the diagnosis was MN1-altered astroblastoma, which presented cell wrapping, i.e., presence of tumor cells enveloping one another. She received local radiotherapy (50 Gy). However, the tumor recurred after 12 years, and its size increased rapidly. The second surgery achieved GTR and confirmed increasing anaplasia. The patient was tumor-free for 1 year without any neurological deficits. This case implies the importance of long-term follow-up of MN1-altered astroblastoma. The pathological significance of cell wrapping in this case is unclear, but it may be associated with MN1-altered astroblastoma and should be noted in future cases.

星形母细胞瘤是一种极为罕见的脑肿瘤，由于其与MN1基因改变相关，最近引起了人们的注意。然而，其长期临床过程仍不清楚。我们报告了具有独特病理学发现的MN1改变的星形母细胞瘤的晚期复发。一名 24 岁女性因左额叶肿瘤而出现癫痫发作。实现了大体全切（GTR），诊断为MN1- 改变的星形母细胞瘤，呈现细胞包裹，即存在彼此包裹的肿瘤细胞。她接受了局部放射治疗（50 Gy）。然而，肿瘤在12年后复发，并且其体积迅速增大。第二次手术实现了 GTR 并确认了不发育的增加。患者无肿瘤 1 年，无任何神经功能缺损。该病例暗示了对MN1改变的星形母细胞瘤进行长期随访的重要性。在这种情况下细胞包裹的病理意义尚不清楚，但它可能与MN1改变的星形母细胞瘤有关，应在未来的病例中加以注意。