In this study, marine mussels (Mytilus coruscus) were exposed to three typical PAEs (dimethyl phthalate [DMP], dibutyl phthalate [DBP] and di(2-ethylhexyl) phthalate [DEHP]) at a range of doses for different times to investigate the ecotoxicological effects. The accumulation of the three PAE congeners in M. coruscus exhibited the following trend: DEHP > DBP > DMP. The antioxidant response of mussel gonadal tissue was enhanced with increasing concentrations of PAEs. For the DBP and DEHP treatment groups, glutathione (GSH) worked in concert with antioxidant enzymes to protect cells against reactive oxygen species (ROS), while GSH played a prominent antioxidant role in the DMP-treated group. The metabolomics results revealed that PAE exposure disrupted the metabolic balance of mussels. Overall, PAEs affect the amino acid metabolism, lipid metabolism, energy metabolism, osmoregulation and nerve activities of mussels. Our results provide further insight into the toxicological effects of PAEs on marine organisms.

在这项研究中，将贻贝（Mytilus coruscus）暴露于三种典型的PAEs（邻苯二甲酸二甲酯[DMP]，邻苯二甲酸二丁酯[DBP]和邻苯二甲酸二[2-乙基己基]酯[DEHP]），并在不同的时间进行剂量研究。生态毒理作用。Coruscus M. coruscus中三个PAE同源物的积累表现出以下趋势：DEHP> DBP> DMP。贻贝性腺组织的抗氧化反应随着PAEs浓度的增加而增强。对于DBP和DEHP治疗组，谷胱甘肽（GSH）与抗氧化酶协同作用，以保护细胞免受活性氧（ROS）的侵害，而GSH在DMP治疗组中起着重要的抗氧化作用。代谢组学结果表明，暴露于PAE会破坏贻贝的代谢平衡。总体而言，PAE影响贻贝的氨基酸代谢，脂质代谢，能量代谢，渗透调节和神经活动。我们的结果为PAE对海洋生物的毒理学作用提供了进一步的见识。