Epidemiological evidence suggests that adverse environmental factors in the nasal cavity may increase the risk for neuropsychiatric diseases. For instance, air pollution and nasal viral infection have been underscored as risk factors for Parkinson’s disease, schizophrenia, and mood disorders. These adverse factors can elicit local inflammation in the nasal cavity, which may in turn influence higher brain function. Nevertheless, evidence that directly supports their causal link is missing. To fill this knowledge gap, we used an inducible mouse model for olfactory inflammation and showed the evidence that this local pathological factor can elicit behavioral abnormalities.

中文翻译：

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鼻腔局部炎症对高级脑功能和认知的因果影响

流行病学证据表明，鼻腔内的不良环境因素可能会增加神经精神疾病的风险。例如，空气污染和鼻病毒感染被认为是帕金森病、精神分裂症和情绪障碍的危险因素。这些不利因素会引起鼻腔局部炎症，进而影响高级大脑功能。然而，缺乏直接支持其因果关系的证据。为了填补这一知识空白，我们使用了嗅觉炎症的诱导小鼠模型，并证明了这种局部病理因素可以引发行为异常。