Here, we present a bone implant system of phase-oriented titanium dioxide (TiO₂) fabricated by the micro-arc oxidation method (MAO) on β-Ti to facilitate improved osseointegration. This (101) rutile-phase-dominant MAO TiO₂ (R-TiO₂) is biocompatible due to its high surface roughness, bone-mimetic structure, and preferential crystalline orientation. Furthermore, (101) R-TiO₂ possesses active and abundant hydroxyl groups that play a significant role in enhancing hydroxyapatite formation and cell adhesion and promote cell activity leading to osseointegration. The implants had been elicited their favorable cellular behavior in vitro in the previous publications; in addition, they exhibit excellent shear strength and promote bone–implant contact, osteogenesis, and tissue formation in vivo. Hence, it can be concluded that this MAO R-TiO₂ bone implant system provides a favorable active surface for efficient osseointegration and is suitable for clinical applications.

在这里，我们提出了一种通过微弧氧化法 (MAO) 在 β-Ti 上制造的相取向二氧化钛 (TiO ₂ )骨植入系统，以促进骨整合。这种 (101) 金红石相占主导地位的 MAO TiO ₂ (R-TiO ₂ ) 由于其高表面粗糙度、仿骨结构和优先结晶取向而具有生物相容性。此外，(101) R-TiO ₂具有活性和丰富的羟基，在促进羟基磷灰石形成和细胞粘附方面发挥重要作用，促进细胞活性，导致骨整合。在之前的出版物中，植入物已经在体外引发了良好的细胞行为；此外，它们表现出优异的剪切强度并促进体内骨与植入物的接触、成骨和组织形成。因此，可以得出结论，该 MAO R-TiO ₂骨植入系统为有效的骨整合提供了有利的活性表面，并且适用于临床应用。