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Statin effect on coronary calcium distribution, mass and volume scores and associations with immune activation among HIV+ persons on antiretroviral therapy.
Antiviral Therapy ( IF 1.2 ) Pub Date : 2021-04-26 , DOI: 10.3851/imp3389
Jerry Lipinski 1 , Seunghee Margevicius 2 , Mark D Schluchter 2 , David L Wilson 3 , Grace A McComsey 2, 4 , Chris T Longenecker 2, 4
Affiliation  

Inflammation has been associated with whole heart coronary artery calcification (CAC) among people with HIV (PWH) on antiretroviral therapy (ART); however, prior studies have not evaluated the distribution of calcium or separated mass vs. volume scores, which are differentially associated with clinical events in the general population. Statins may also have a greater effect on CAC mass compared to volume.

中文翻译:

他汀类药物对接受抗逆转录病毒治疗的 HIV+ 人群冠状动脉钙分布、质量和体积评分以及与免疫激活的关联的影响。

在接受抗逆转录病毒治疗 (ART) 的 HIV 感染者 (PWH) 中,炎症与全心脏冠状动脉钙化 (CAC) 相关;然而,先前的研究没有评估钙的分布或分离的质量与体积评分,这些评分与一般人群的临床事件有不同的相关性。与体积相比,他汀类药物对 CAC 质量的影响也可能更大。
更新日期:2021-04-28
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