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Clinical outcome of SARS-CoV-2 infection in 7 adults with Duchenne muscular dystrophy attending a specialist neuromuscular centre
Neuromuscular Disorders ( IF 2.8 ) Pub Date : 2021-04-27 , DOI: 10.1016/j.nmd.2021.04.005
Ros Quinlivan 1 , Mahalekshmi Desikan 2 , Francis Cruces 2 , Aleksandra Pietrusz 3 , Konstantinos Savvatis 4
Affiliation  

Due to their frailty and cardiorespiratory compromise adults with DMD are considered extremely vulnerable and at high risk of severe infection should they contract COVID-19. We report 7 adults with DMD aged 17–26 years who tested positive on a nasopharyngeal PCR swab for SARS-CoV-2. Despite long term corticosteroid treatment, severe respiratory compromise requiring night-time ventilation and receiving treatment for moderate to severe cardiomyopathy, none of the patients developed moderate to severe symptoms; in fact two remained asymptomatic and two developed only anosmia and reduced sensation. The remaining three developed transient fever with or without sore throat, cough and runny nose. All recovered fully without complication and no patient required hospitalization.



中文翻译:

在专科神经肌肉中心就诊的 7 名杜兴氏肌营养不良症成人感染 SARS-CoV-2 的临床结果

由于患有 DMD 的成年人身体虚弱和心肺功能受损,因此被认为是极度脆弱的,如果他们感染 COVID-19,则面临严重感染的高风险。我们报告了 7 名 17-26 岁的 DMD 成年人,他们的 SARS-CoV-2 鼻咽 PCR 拭子检测呈阳性。尽管进行了长期的皮质类固醇治疗、需要夜间通气的严重呼吸系统损害并接受了中度至重度心肌病的治疗,但没有患者出现中度至重度症状;事实上,其中两人没有出现症状,另外两人仅出现嗅觉丧失和感觉减退。其余三人出现短暂发烧,伴有或不伴有喉咙痛、咳嗽和流鼻涕。所有患者都完全康复,没有并发症,也没有患者需要住院。

更新日期:2021-04-27
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