Autism spectrum disorder (ASD) is a developmental disorder characterized by defects in social interaction. The past functional connectivity studies using resting-state fMRI have found both patterns of hypo-connectivity and hyper-connectivity in ASD and proposed the age as an important factor on functional connectivity disorders. However, this influence is not clearly characterized yet. Previous studies have often examined the functional connectivity disorders in particular brain regions in an age group or a mixture of age groups. The present study compares whole-brain within-connectivity and between-connectivity between ASD individuals and typically developing (TD) controls in three age groups including children (< 11 years), adolescents (11–18 years), and adults (> 18 years), each comprising 21 ASD individuals and 21 TD controls. The age groups were matched for age, Full IQ, and gender. Independent component analysis and dual regression were used to investigate within-connectivity. The full and partial correlations between ICs were used to investigate between-connectivity. Examination of the within-connectivity showed hyper-connectivity, especially in cerebellum and brainstem in ASD children but both hyper/hypo connectivity in adolescents and ASD adults. In ASD children, difference in the between-connectivity among default mode network (DMN), salience-executive network and fronto-parietal network were observed. There was also a negative correlation between DMN and temporal network. Full correlation comparison between ASD adolescents and TD individuals showed significant differences between cerebellum and DMN. Our results supported just the hyper-connectivity in childhood, but both hypo and hyper-connectivity after childhood and hypothesized that abnormal resting connections in ASD exist in the regions of the brain known to be involved in social cognition.

自闭症谱系障碍（ASD）是一种发展障碍，其特征是社交互动方面的缺陷。过去使用静止状态功能磁共振成像进行的功能连通性研究已经发现ASD的低连通性和超连通性两种模式，并提出年龄是影响功能连通性疾病的重要因素。但是，这种影响尚不明确。先前的研究经常检查年龄组或年龄组混合人群中特定大脑区域的功能连接障碍。本研究比较了三个年龄段的ASD个体与典型发育（TD）控件之间的全脑内连接和内连接之间的关系，包括儿童（<11岁），青少年（11-18岁）和成人（> 18岁） ），每个都包含21名ASD个体和21名TD对照。根据年龄，完全智商和性别对年龄组进行匹配。使用独立成分分析和对偶回归研究内在联系。IC之间的全部和部分相关性用于研究互连性。内连通性检查显示超连通性，特别是在ASD儿童的小脑和脑干中，但在青少年和ASD成人中都存在超/低连通性。在ASD儿童中，观察到默认模式网络（DMN），显着执行网络和额顶网络之间的互连性差异。DMN和时间网络之间也存在负相关。ASD青少年与TD个体之间的完全相关性比较显示，小脑与DMN之间存在显着差异。我们的结果仅支持儿童时期的超连通性，