¹⁸F-labeled 2-arylbenzoxazole derivative (S)-[¹⁸F]28 is potent and selective radiopharmaceutical Aβ tracers for Alzheimer's disease positron-emission tomography (PET). Our study aimed to enable facile preparation of (S)-[¹⁸F]28 in commercially available PET tracer production facilities to promote the widespread application and clinical translation. Here, we successfully demonstrated an automated radiosynthesis of (S)-[¹⁸F]28 with high radiochemical yield and radiochemical purity by the AllinOne radiosynthesis module. The method developed here can facilitate extensive use of (S)-[¹⁸F]28 in large-scale clinical trials.

¹⁸ F-标记的 2-芳基苯并恶唑衍生物 (S)-[ ¹⁸ F]28 是用于阿尔茨海默病正电子发射断层扫描 (PET) 的有效且选择性的放射性药物 Aβ 示踪剂。我们的研究旨在使 (S)-[ ¹⁸ F]28 能够在市售的 PET 示踪剂生产设施中轻松制备，以促进广泛应用和临床转化。在这里，我们通过 AllinOne 放射合成模块成功地展示了 (S)-[ ¹⁸ F]28的自动放射合成，具有高放射化学产率和放射化学纯度。这里开发的方法可以促进 (S)-[ ¹⁸ F]28 在大规模临床试验中的广泛使用。