Abstract

There is growing evidence of the relationship between Metabolic Syndrome (MetS) and cognitive decline; however, this has not been conclusively established yet. This systematic review and meta-analysis address the most crucial cognitive performance findings, including those on global cognitive function, memory, attention, and executive functions, in adult people with MetS. Two electronic databases were searched (April–May 2020) using the terms “metabolic syndrome” and “cognition,” including publications from 2010 to 2020. Thirty-six studies were found. Among these, 17 reported negative associations in cognition with MetS, mainly in terms of verbal memory and executive functions, particularly in the middle-aged population. A meta-analysis of global cognitive function revealed that the MetS group had a lower score than the control group (25.26 and 25.6, respectively, 95% CI, −0.60 to −0.12, p = 0.004). MetS is related to the enhanced presentation of cognitive impairment and its evolution into a Major Neurocognitive Disorder (MND). Further research involving longitudinal studies, including assessments with similar instruments, correctly separated by age group and education, is required.

摘要

越来越多的证据表明代谢综合征（MetS）与认知能力下降之间的关系。但是，这还没有最终确定。这项系统的回顾和荟萃分析解决了成年人MetS的最关键的认知表现发现，包括有关整体认知功能，记忆，注意力和执行功能的发现。使用“代谢综合征”和“认知”一词检索了两个电子数据库（2020年4月至2020年5月），包括2010年至2020年的出版物。共发现了36​​项研究。其中，有17个报告与MetS的认知呈负相关，主要在言语记忆和执行功能方面，特别是在中年人群中。对全球认知功能的荟萃分析显示，MetS组的得分低于对照组（25.26和25。在图6中，分别为95％CI，-0.60至-0.12，p ＝ 0.004）。MetS与认知障碍的增强表现及其演变为主要神经认知障碍（MND）有关。需要进行涉及纵向研究的进一步研究，包括使用类似工具进行的评估，并按年龄组和受教育程度正确区分。