Abstract

Astronauts embarking on deep space missions are at high risk of long-term exposure to low doses of high linear energy transfer (LET) radiation, which can contribute to the development of cancer and multiple degenerative diseases. However, long term effects of exposure to low doses of high LET radiation in plasma metabolite profiles have not been elucidated. We utilized an untargeted metabolomics and lipidomics approach to analyze plasma obtained from adult male Long Evans rats to determine the longitudinal effects of low-dose proton and low-dose oxygen ion whole-body irradiation on metabolic pathways. Our findings reveal that radiation exposure induced modest changes in the metabolic profiles in plasma, 7 months after exposure. Furthermore, we identified some common metabolite dysregulations between protons and oxygen ions, which may indicate a similar mechanism of action for both radiation types.

摘要

执行深空任务的宇航员长期暴露于低剂量高线性能量转移 (LET) 辐射的风险很高，这可能导致癌症和多种退行性疾病的发展。然而，尚未阐明暴露于低剂量高 LET 辐射对血浆代谢物谱的长期影响。我们利用非靶向代谢组学和脂质组学方法分析从成年雄性 Long Evans 大鼠获得的血浆，以确定低剂量质子和低剂量氧离子全身照射对代谢途径的纵向影响。我们的研究结果表明，辐射暴露在暴露 7 个月后会引起血浆代谢特征的适度变化。此外，我们确定了质子和氧离子之间一些常见的代谢物失调，