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The Biological Activity of Designer Drugs from the Group of Synthetic Opioids
Biology Bulletin Reviews Pub Date : 2021-04-27 , DOI: 10.1134/s2079086421020031
A. I. Golovko , Ju. Ju. Ivnitsky , M. B. Ivanov , V. L. Rejniuk , V. K. Kozlov

Abstract

Information on the biological activity of designer synthetic opioids is presented. The classifications of such agents are reviewed. Comparisons of synthetic opioids and opium alkaloids are given for analgesic and addictive effects and the ability to cause respiratory depression. The unusual biological activity of designer opioids is based on their high affinity for µ-opioid receptors, pronounced agonistic properties, and the ease of their ability to cross the blood-brain barrier. The presented biological characteristics allow designer synthetic opioids to be classified as the most dangerous drugs in illicit traffic.



中文翻译:

合成阿片类药物中设计药物的生物活性

摘要

介绍了有关合成合成阿片类药物的生物活性的信息。审查了这些代理的分类。比较了合成阿片类药物和鸦片生物碱的镇痛和成瘾作用以及引起呼吸抑制的能力。设计类阿片类药物的非凡生物学活性是基于它们对μ阿片类药物受体的高度亲和力,明显的激动性以及其穿越血脑屏障的能力。所呈现的生物学特性使设计合成的阿片类药物可被分类为非法贩运中最危险的药物。

更新日期:2021-04-28
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