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Respiratory RNA Viruses: How to Be Prepared for an Encounter with New Pandemic Virus Strains
Biology Bulletin Reviews Pub Date : 2021-04-27 , DOI: 10.1134/s207908642102002x
S. V. Chepur , N. N. Pluzhnikov , O. V. Chubar , L. S. Bakulina , I. V. Litvinenko , V. A. Makarov , A. S. Gogolevsky , V. A. Myasnikov , I. A. Myasnikova , R. I. Al-Shehadat

Abstract

The characteristics of the biology of influenza viruses and coronavirus that determine the implementation of the infectious process are presented. With provision for pathogenesis of infection possible effects of serine proteinase inhibitors, heparin, and inhibitors of heparan sulfate receptors in the prevention of cell contamination by viruses are examined. It has been determined that chelators of metals of variable valency and antioxidants should be used for the reduction of replicative activity of viruses and anti-inflammatory therapy. The possibility of a pH-dependent impairment of glycosylation of cellular and viral proteins was traced for chloroquine and its derivatives. The use of low-toxicity drugs as part of adjunct therapy increases the effectiveness of synthetic antiviral drugs and interferons and ensures the safety of baseline therapy.



中文翻译:

呼吸RNA病毒:如何为新的大流行病毒株的遭遇做好准备

摘要

介绍了决定感染过程实施的流感病毒和冠状病毒的生物学特性。考虑到感染的发病机理,研究了丝氨酸蛋白酶抑制剂,肝素和硫酸乙酰肝素受体抑制剂在预防病毒引起的细胞污染中的可能作用。已经确定,应使用化合价可变的金属和抗氧化剂的螯合剂来减少病毒的复制活性和抗炎治疗。对于氯喹及其衍生物,追踪了pH依赖性的细胞和病毒蛋白糖基化损害的可能性。将低毒性药物用作辅助治疗的一部分,可以提高合成抗病毒药物和干扰素的有效性,并确保基线治疗的安全性。

更新日期:2021-04-28
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