当前位置: X-MOL 学术Annu. Rev. Immunol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Immunosensation: Neuroimmune Cross Talk in the Skin
Annual Review of Immunology ( IF 29.7 ) Pub Date : 2021-04-26 , DOI: 10.1146/annurev-immunol-101719-113805
Masato Tamari 1, 2, 3 , Aaron M Ver Heul 2, 4 , Brian S Kim 1, 2, 5, 6
Affiliation  

Classically, skin was considered a mere structural barrier protecting organisms from a diversity of environmental insults. In recent decades, the cutaneous immune system has become recognized as a complex immunologic barrier involved in both antimicrobial immunity and homeostatic processes like wound healing. To sense a variety of chemical, mechanical, and thermal stimuli, the skin harbors one of the most sophisticated sensory networks in the body. However, recent studies suggest that the cutaneous nervous system is highly integrated with the immune system to encode specific sensations into evolutionarily conserved protective behaviors. In addition to directly sensing pathogens, neurons employ novel neuroimmune mechanisms to provide host immunity. Therefore, given that sensation underlies various physiologies through increasingly complex reflex arcs, a much more dynamic picture is emerging of the skin as a truly systemic organ with highly coordinated physical, immunologic, and neural functions in barrier immunology.

中文翻译:


免疫感觉:皮肤中的神经免疫串扰

传统上,皮肤被认为仅仅是保护生物体免受各种环境侵害的结构屏障。近几十年来,皮肤免疫系统已被认为是一种复杂的免疫屏障,涉及抗菌免疫和伤口愈合等稳态过程。为了感知各种化学、机械和热刺激,皮肤拥有体内最复杂的感觉网络之一。然而,最近的研究表明,皮肤神经系统与免疫系统高度整合,将特定的感觉编码为进化上保守的保护行为。除了直接感知病原体外,神经元还采用新的神经免疫机制来提供宿主免疫。所以,

更新日期:2021-04-27
down
wechat
bug