当前位置: X-MOL 学术Annu. Rev. Immunol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Epigenetic Remodeling in Innate Immunity and Inflammation
Annual Review of Immunology ( IF 29.7 ) Pub Date : 2021-04-26 , DOI: 10.1146/annurev-immunol-093019-123619
Qian Zhang 1, 2 , Xuetao Cao 1, 2, 3
Affiliation  

The innate immune response is a rapid response to pathogens or danger signals. It is precisely activated not only to efficiently eliminate pathogens but also to avoid excessive inflammation and tissue damage. cis-Regulatory element–associated chromatin architecture shaped by epigenetic factors, which we define as the epiregulome, endows innate immune cells with specialized phenotypes and unique functions by establishing cell-specific gene expression patterns, and it also contributes to resolution of the inflammatory response. In this review, we focus on two aspects: (a) how niche signals during lineage commitment or following infection and pathogenic stress program epiregulomes by regulating gene expression levels, enzymatic activities, or gene-specific targeting of chromatin modifiers and (b) how the programed epiregulomes in turn mediate regulation of gene-specific expression, which contributes to controlling the development of innate cells, or the response to infection and inflammation, in a timely manner. We also discuss the effects of innate immunometabolic rewiring on epiregulomes and speculate on several future challenges to be encountered during the exploration of the master regulators of epiregulomes in innate immunity and inflammation.

中文翻译:


先天免疫和炎症的表观遗传重塑

先天免疫反应是对病原体或危险信号的快速反应。它被精确激活,不仅可以有效消除病原体,还可以避免过度炎症和组织损伤。由表观遗传因子形成的与顺式调控元件相关的染色质结构,我们将其定义为表观调控组,通过建立细胞特异性基因表达模式赋予先天免疫细胞特殊的表型和独特的功能,它还有助于解决炎症反应。在这次审查中,我们重点关注两个方面:()通过调节基因表达水平、酶活性或染色质修饰物的基因特异性靶向,在谱系承诺期间或感染和病原应激后,生态位信号如何程序化上皮调节体,以及(b)程序化的上皮调节体如何反过来介导基因特异性表达的调节,这有助于及时控制先天细胞的发育或对感染和炎症的反应。我们还讨论了先天免疫代谢重新布线对表皮细胞的影响,并推测在探索先天免疫和炎症中表皮细胞的主要调节因子期间将遇到的几个未来挑战。

更新日期:2021-04-27
down
wechat
bug