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The role of the endogenous oxytocin system under psychosocial stress conditions in adolescents suffering from anxiety disorder: study protocol for a parallel group controlled trial
BMC Psychology ( IF 2.588 ) Pub Date : 2021-04-26 , DOI: 10.1186/s40359-021-00564-z
Leonie Goetz , Irina Jarvers , Daniel Schleicher , Kathrin Mikan , Romuald Brunner , Stephanie Kandsperger

In social neuroscience, the linkage between the endocrinological system and the etiology and symptomatology of mental health problems has received increasing attention. A particular focus is given to the neuropeptide oxytocin with its anxiolytic and stress-buffering effect and the resulting therapeutic potential for anxiety disorders. Even though anxiety disorders are the most prevalent mental health disorders in childhood and adolescence worldwide, the reactivity of the endogenous oxytocin system to an acute stressor (Trier Social Stress Test, TSST) has so far only been investigated in healthy children. It has been shown that peripheral oxytocin levels increased under psychosocial stress conditions. In the present study, it is hypothesized that the endogenous oxytocin system in children and adolescents suffering from a clinically diagnosed anxiety disorder is dysregulated. Three primary outcome parameters will be analyzed: significant differences between participants with anxiety disorders compared to healthy controls in basal oxytocin levels, varying salivary oxytocin release after stress exposure and the correlation between the cortisol peak/-decrease and oxytocin level over time. Secondary outcome criteria are significant differences in physiological (heart rate) and psychological (perceived stress, anxiety, insecurity, tension) responses. The present study is a single-center experimental observation study to investigate the reactivity of the endocrinological system to a psychosocial stressor (TSST). 32 children and adolescents (11–18 years) suffering from anxiety disorder will be compared to a matched healthy control group. After a detailed psychological assessment, saliva samples will be taken to measure oxytocin levels before and after psychosocial stress exposure at eight different time points. Additionally, the stress hormone cortisol will be analyzed according to the same procedure. Due to the high prevalence and comorbidity rate with numerous other psychiatric disorders and mental health problems, there is an urgent need to strengthen research in possible neurobiological underpinnings of anxiety disorders. To our knowledge, the proposed experiment is the first study to examine the endocrinological oxytocin and cortisol reaction to an acute psychosocial stressor in children and adolescents with mental health disorders. Trial registration The study is registered in the German Clinical Trials Register since 11 September 2019, DRKS00017793, https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00017793 .

中文翻译:

心理应激条件下内源性催产素系统在焦虑症青少年中的作用:平行对照组的研究方案

在社会神经科学中,内分泌系统与精神健康问题的病因和症状之间的联系日益受到关注。特别关注神经肽催产素,其具有抗焦虑和缓解压力作用,以及由此产生的治疗焦虑症的潜力。尽管焦虑症是全世界儿童和青少年中最普遍的心理健康疾病,但迄今为止,仅在健康儿童中研究了内源性催产素系统对急性应激源的反应性(特里尔社会压力测试,TSST)。已经表明,在社会心理压力条件下外周催产素水平增加。在目前的研究中,假设患有临床诊断的焦虑症的儿童和青少年的内源性催产素系统失调。将分析三个主要结局参数:与健康对照组相比,焦虑症参与者的基础催产素水平存在显着差异,压力暴露后唾液催产素释放量的变化以及皮质醇峰值/减少量与催产素水平之间的相关性。次要结果标准是生理(心率)和心理(感知压力,焦虑,不安全感,紧张)反应的显着差异。本研究是一项单中心实验观察研究,旨在研究内分泌系统对心理社会压力源(TSST)的反应性。将32名患有焦虑症的儿童和青少年(11-18岁)与相匹配的健康对照组进行比较。经过详细的心理评估后,将在八个不同时间点,在社会心理压力暴露前后,采集唾液样本以测定催产素水平。另外,应激激素皮质醇将根据相同的程序进行分析。由于许多其他精神疾病和精神健康问题的高患病率和合并症发生率,迫切需要加强对焦虑症可能的神经生物学基础的研究。就我们所知,拟议的实验是第一个研究内分泌学的催产素和皮质醇对患有精神疾病的儿童和青少年对急性心理应激源的反应的研究。
更新日期:2021-04-26
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