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Pharmacological or non-pharmacological interventions for treatment of common mental disorders associated with Tuberculosis: A systematic review
Chronic Respiratory Disease ( IF 4.1 ) Pub Date : 2021-04-26 , DOI: 10.1177/14799731211003937
Saeed Farooq 1, 2 , Jessica Tunmore 2 , Rifat Comber 2
Affiliation  

We aimed to review the literature on interventions for treating Common Mental Disorders (CMD) in people with Tuberculosis (TB). We followed PRISMA guidelines and the protocol was registered at PROSPERO. The electronic databases (PsycInfo, CINAHL, Medline, Google Scholar, Embase) were searched from 1982 to 2020. 349 relevant records were screened, with 26 examined at full text. 13 studies were included totalling 4326 participants. A meta-analysis was not possible due to nature of data, thus descriptive synthesis was conducted. Eleven studies evaluated psychosocial interventions, which significantly improved adherence or cure rates from TB, anxiety and depression. The elements of effective psychosocial interventions included; combating stigma, socioeconomic disadvantage, managing associated guilt and fear of contagion, and explanatory models of illness in local population. Two articles evaluated pharmacological interventions (antidepressants and Vitamin D). This is the first systematic review of interventions to treat CMD in TB. The studies were mostly low quality and mental health outcomes were not adequately described. However, this review suggests that it is feasible to develop and test interventions for improving mental health outcomes and enhancing treatment adherence in TB.



中文翻译:

治疗与结核病相关的常见精神障碍的药物或非药物干预:系统评价

我们旨在回顾有关治疗结核病 (TB) 患者常见精神障碍 (CMD) 的干预措施的文献。我们遵循 PRISMA 指南,该协议已在 PROSPERO 注册。检索1982年至2020年的电子数据库(PsycInfo、CINAHL、Medline、Google Scholar、Embase),筛选相关记录349条,全文检索26条。共纳入 13 项研究,共有 4326 名参与者。由于数据的性质,无法进行荟萃分析,因此进行了描述性综合。11 项研究评估了心理社会干预措施,这些干预措施显着提高了结核病、焦虑和抑郁症的依从性或治愈率。有效的社会心理干预的要素包括:与污名、社会经济劣势作斗争,管理相关的内疚和对传染的恐惧,和当地人群疾病的解释模型。两篇文章评估了药物干预(抗抑郁药和维生素 D)。这是对治疗 TB 中 CMD 干预措施的首次系统评价。这些研究大多是低质量的,没有充分描述心理健康结果。然而,该综述表明,开发和测试干预措施以改善心理健康结果和提高结核病治疗依从性是可行的。

更新日期:2021-04-27
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