In this research work composite coatings made of alginate and 45S5 bioactive glass particles doped with B, Zn or Sr were synthesized by means of electrophoretic deposition and characterized from morphological, compositional, thermogravimetric, mechanical and electrochemical points of view. The developed coatings were also subjected to in vitro test in SBF solution to evaluate their ability to induce hydroxyapatite precipitation and cytocompatibility evaluation using human primary fibroblasts.

The obtained results demonstrated a good homogeneity of the coatings, high adhesion and a protective behavior towards the substrate. The thermogravimetric analysis proved that the glass amount was constant before and after the deposition and all the investigated coatings promoted the deposition of hydroxyapatite but with different kinetics. Since the Zn containing coating showed the best bioactive behavior it was subjected to cytocompatibility test, which demonstrated, after an initial reduction of cell viability, a good cell proliferation and the production of collagen from the ECM. These findings suggest that the obtained coatings are promising materials to coat metallic prosthetic devices.

在这项研究工作中，通过电泳沉积法合成了藻酸盐和掺有B，Zn或Sr的45S5生物活性玻璃颗粒制成的复合涂层，并从形态，组成，热重，机械和电化学的角度对其进行了表征。所开发的涂层也要在SBF溶液中进行体外测试，以评估其诱导羟磷灰石沉淀的能力以及使用人原代成纤维细胞的细胞相容性评估。

获得的结果证明了涂层的良好均质性，高粘附性和对基材的保护性能。热重分析表明，沉积前后的玻璃量是恒定的，所有研究的涂层均促进了羟基磷灰石的沉积，但动力学不同。由于含锌涂层显示出最佳的生物活性，因此对其进行了细胞相容性测试，该测试表明，在最初降低细胞活力后，细胞具有良好的增殖能力，并且由ECM产生胶原蛋白。这些发现表明，获得的涂层是用于涂覆金属修复装置的有前途的材料。