Small Ruminant Research ( IF 1.8 ) Pub Date : 2021-04-26 , DOI: 10.1016/j.smallrumres.2021.106395 Mohmmad Abrar Gayas , Mujeeb R. Fazili , Nida Handoo , Abrar A. Malik , Raja Aijaz , Syed Tahreem , Haris R. Beigh , Aamir S. Teeli , Riaz A. Shah
A blinded, randomized, prospective experimental study was planned to compare the use of 1% and 2% lidocaine hydrochloride (LH) for distal paravertebral nerve block (DPNB) in Bakerwal goats undergoing reproductive laparoscopy. The goats (n = 13) were randomly allotted to two treatments: Treatment I (n = 7) and Treatment II (n = 6) and injected 15.0 mL of either 1% or 2% LH. Nociceptive stimuli during pre- and postoperative periods comprised of superficial and deep pinpricks. The reaction of the animals to the surgical intervention and alterations in their behaviour were recorded intraoperatively. The time to inject the anesthetic (5.4 ± 1.6 and 4.9 ± 0.9 min), onset time (2.6 ± 1.6 and 2.3 ± 1.4 min), the incision length (5.0 ± 1.4 cm and 4.7 ± 1.7 cm) and the sensory blockade duration (121 ± 18 and 123 ± 17 min) in Treatment I and Treatment II goats respectively showed no significant difference. In Treatment I goats the anesthetic dose (5.2 ± 1.1 mg kg -1) injected was significantly less than Treatment II (9.8 ± 0.8 mg kg -1) but their laparoscopy time (73 ± 25 min) was significantly more than Treatment II (56 ± 4 min) animals. The satisfactory sensory blockade lasted for similar period; Treatment I (121 ± 18 min) and Treatment II (123 ± 17 min). The physiological parameters fluctuated most of the times within the normal range. Signs of toxicity, acute pain or distress were not recorded in any of the animals. From this study it is concluded that satisfactory sensory blockade develops after DPNB using either 2% or 1% LH in goats. However, further trials involving higher number of healthy and ailing animals and evaluation of other nerve blocks are needed before advocating the routine use of 1% preparation in the caprine clinical practice.
中文翻译:
接受生殖腹腔镜检查的山羊的远端椎旁神经阻滞:1%和2%的盐酸利多卡因是否同样有效?
计划进行一项盲目,随机,前瞻性实验研究,以比较在进行生殖腹腔镜检查的贝克韦尔山羊中,使用1%和2%的盐酸利多卡因(LH)治疗远端椎旁神经阻滞(DPNB)的情况。将山羊(n = 13)随机分配给两种处理:处理I(n = 7)和处理II(n = 6),并注射15.0 mL 1%或2%LH。术前和术后的伤害性刺激包括浅表和深层针刺。术中记录动物对手术干预的反应及其行为的改变。注射麻醉剂的时间(5.4±1.6和4.9±0.9分钟),起效时间(2.6±1.6和2.3±1.4分钟),切口长度(5.0±1.4 cm和4.7±1。治疗I和治疗II山羊的感觉障碍持续时间分别为7厘米(121厘米±18分钟和123±17分钟),无明显差异。在治疗I山羊中,注射的麻醉剂量(5.2±1.1 mg kg -1)明显小于治疗II(9.8±0.8 mg kg -1),但腹腔镜检查时间(73±25分钟)明显大于治疗II(56) ±4分钟)动物。令人满意的感觉阻滞持续了相似的时间。处理I(121±18分钟)和处理II(123±17分钟)。生理参数在正常范围内大部分时间波动。在任何动物中均未记录到毒性,急性疼痛或困扰的迹象。从这项研究得出的结论是,在山羊中使用2%或1%的LH进行DPNB后,会产生令人满意的感觉阻滞。然而,