Small-molecule kinase inhibitors have made major advances in cancer therapy, but their efficacy remains limited by intrinsic and acquired resistance. The expression and thermostability of the kinase CDK6 are now shown to mediate intrinsic resistance to CDK4/6 inhibitors and degraders across cancer types.

中文翻译：

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积极应对 CDK4/6 治疗耐药性

小分子激酶抑制剂在癌症治疗方面取得了重大进展，但它们的功效仍然受到内在和获得性耐药性的限制。现在表明，激酶 CDK6 的表达和热稳定性介导了对各种癌症类型的 CDK4/6 抑制剂和降解剂的内在抗性。