We examined seasonal and geographic effects on vitamin D [25(OH)D] levels, association with attention-deficit/hyperactivity disorder (ADHD) symptom severity, and effects of supplementation in 222 children age 7–10 with rigorously diagnosed ADHD. 25(OH)D insufficiency rates were 47.2 % in Ohio and 28.5 % 400 miles south in North Carolina. Nadir of 25(OH)D levels was reached by November in Ohio, not until January in NC. Thirty-eight children with insufficiency/deficiency took vitamin D (1000–2000 IU/day for a month); levels rose 52 %. Although inattention did not correlate with 25(OH)D at screen nor improve significantly with supplementation, inattention improvement after supplementation correlated with 25(OH)D increase (rho = 0.41, p = 0.012). A clinically significant proportion of children with ADHD have insufficient 25(OH)D even at summer’s end, more so in the winter and north of the 37th parallel. The significant correlation of inattention improvement with 25(OH)D increase suggests further research on 25(OH)D as ADHD treatment.

我们检查了季节性和地理对维生素 D [25(OH)D] 水平的影响、与注意力缺陷/多动障碍 (ADHD) 症状严重程度的关联，以及 222 名被严格诊断为 ADHD 的 7-10 岁儿童的补充效果。25(OH)D 不足率在俄亥俄州为 47.2%，在北卡罗来纳州以南 400 英里为 28.5%。25(OH)D 水平的最低点在 11 月在俄亥俄州达到，直到 1 月在北卡罗来纳州。38 名缺乏/缺乏的儿童服用维生素 D（1000-2000 IU/天，持续一个月）；水平上升了 52%。尽管注意力不集中与筛选时的 25(OH)D 无关，也没有显着改善，但补充后注意力不集中的改善与 25(OH)D 增加相关（rho = 0.41，p = 0.012）。即使在夏末，临床上显着比例的多动症儿童的 25(OH)D 不足，在冬季和 37 度线以北更是如此。注意力不集中改善与 25(OH)D 增加的显着相关性表明进一步研究 25(OH)D 作为 ADHD 治疗。