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Embryo implantation in the laboratory: an update on current techniques
Human Reproduction Update ( IF 13.3 ) Pub Date : 2021-01-07 , DOI: 10.1093/humupd/dmaa054
Samuel Ojosnegros 1 , Anna Seriola 1 , Amélie L Godeau 1 , Anna Veiga 2, 3
Affiliation  

The embryo implantation process is crucial for the correct establishment and progress of pregnancy. During implantation, the blastocyst trophectoderm cells attach to the epithelium of the endometrium, triggering intense cell-to-cell crosstalk that leads to trophoblast outgrowth, invasion of the endometrial tissue, and formation of the placenta. However, this process, which is vital for embryo and foetal development in utero, is still elusive to experimentation because of its inaccessibility. Experimental implantation is cumbersome and impractical in adult animal models and is inconceivable in humans.

中文翻译:

实验室中的胚胎植入:当前技术的更新

胚胎植入过程对于妊娠的正确建立和进展至关重要。在植入过程中,胚泡滋养外胚层细胞附着在子宫内膜的上皮细胞上,引发强烈的细胞间串扰,导致滋养层生长、侵入子宫内膜组织和形成胎盘。然而,这个对子宫内胚胎和胎儿发育至关重要的过程,由于其不可接近性,仍然难以进行实验。实验性植入在成年动物模型中既麻烦又不切实际,在人类中也是不可想象的。
更新日期:2021-01-07
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