Delayed parenthood, by both women and men, has become more common in developed countries. The adverse effect of advanced maternal age on embryo aneuploidy and reproductive outcomes is well known. However, whether there is an association between paternal age (PA) and embryonic chromosomal aberrations remains controversial. Oocyte donation (OD) is often utilized to minimize maternal age effects on oocyte and embryo aneuploidy, thus providing an optimal model to assess the effect of PA. Several studies have revealed a higher than expected rate of aneuploidy in embryos derived from young oocyte donors, which warrants examination as to whether this may be attributed to advanced PA (APA).

中文翻译：

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父亲年龄和非整倍体之间是否存在关联？来自年轻供体卵母细胞衍生胚胎的证据：系统评价和个体患者数据荟萃分析

在发达国家，女性和男性的延迟生育已经变得更加普遍。高龄产妇对胚胎非整倍性和生殖结果的不利影响是众所周知的。然而，父亲年龄（PA）与胚胎染色体畸变之间是否存在关联仍存在争议。卵母细胞捐赠 (OD) 通常用于最大限度地减少母体年龄对卵母细胞和胚胎非整倍体的影响，从而为评估 PA 的影响提供最佳模型。几项研究表明，来自年轻卵母细胞供体的胚胎中非整倍体的比率高于预期，这需要检查这是否可能归因于晚期 PA (APA)。