Childhood cancer incidence and survivorship are both on the rise. However, many lifesaving treatments threaten the prepubertal testis. Cryopreservation of immature testicular tissue (ITT), containing spermatogonial stem cells (SSCs), as a fertility preservation (FP) option for this population is increasingly proposed worldwide. Recent achievements notably the birth of non-human primate (NHP) progeny using sperm developed in frozen-thawed ITT autografts has given proof of principle of the reproductive potential of banked ITT. Outlining the current state of the art on FP for prepubertal boys is crucial as some of the boys who have cryopreserved ITT since the early 2000s are now in their reproductive age and are already seeking answers with regards to their fertility.

中文翻译：

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青春期前男孩的生育能力保留：从过去汲取的经验教训和临床转化剩余挑战的最新情况

儿童癌症的发病率和存活率都在上升。然而，许多挽救生命的治疗威胁着青春期前的睾丸。世界范围内越来越多地提出冷冻保存含有精原干细胞 (SSC) 的未成熟睾丸组织 (ITT) 作为该人群的生育力保存 (FP) 选择。最近的成就，尤其是使用在冷冻解冻的 ITT 自体移植物中开发的精子的非人类灵长类动物 (NHP) 后代的诞生，证明了银行 ITT 的生殖潜力原理。概述青春期前男孩 FP 的当前最新状态至关重要，因为自 2000 年代初以来冷冻保存 ITT 的一些男孩现在正处于生育年龄，并且已经在寻求有关其生育能力的答案。